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- W1986288210 abstract "Abstract Prion diseases are enigmatic, neurodegenerative disorders affecting several mammalian species. The family of diseases include scrapie of sheep, bovine spongiform encephalopathy (BSE), Creutzfeldt-Jakob disease (CJD) of humans and chronic wasting disease (CWD) in deer and elk. Prion diseases are believed to be caused by the misfolding of an endogenous host protein and the abnormal, protease-resistant isoform of this protein is suggested to represent the infectious entity. Through many transmission experiments, we know much about the course of prion diseases and the ensuing pathology in the central nervous system. However, few of the causative mechanisms have been deciphered at a level that allows prediction of the disease characteristics of novel prion strains or that allows rational design of chemo-therapeutics. This review article outlines the state of our knowledge of prion disease mechanisms from the concept of protein misfolding, through the factors that may encode different strains of disease, mechanisms of neuronal loss and the ways that disease are transmitted." @default.
- W1986288210 created "2016-06-24" @default.
- W1986288210 creator A5008085821 @default.
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- W1986288210 creator A5045360971 @default.
- W1986288210 creator A5082389792 @default.
- W1986288210 creator A5083887972 @default.
- W1986288210 date "2011-10-12" @default.
- W1986288210 modified "2023-09-23" @default.
- W1986288210 title "The mechanisms of prion disease." @default.
- W1986288210 cites W104301803 @default.
- W1986288210 cites W12959715 @default.
- W1986288210 cites W1455622067 @default.
- W1986288210 cites W1483340343 @default.
- W1986288210 cites W1486755788 @default.
- W1986288210 cites W1488907068 @default.
- W1986288210 cites W1501494207 @default.
- W1986288210 cites W1502117212 @default.
- W1986288210 cites W1503830825 @default.
- W1986288210 cites W1504313755 @default.
- W1986288210 cites W1504399240 @default.
- W1986288210 cites W1512131999 @default.
- W1986288210 cites W1513744325 @default.
- W1986288210 cites W1518703223 @default.
- W1986288210 cites W1520668014 @default.
- W1986288210 cites W1521736247 @default.
- W1986288210 cites W1523600076 @default.
- W1986288210 cites W1527955859 @default.
- W1986288210 cites W1530155692 @default.
- W1986288210 cites W1534728973 @default.
- W1986288210 cites W1538230865 @default.
- W1986288210 cites W1541148800 @default.
- W1986288210 cites W1557724928 @default.
- W1986288210 cites W1563777667 @default.
- W1986288210 cites W1572412686 @default.
- W1986288210 cites W1591693496 @default.
- W1986288210 cites W1591864042 @default.
- W1986288210 cites W1610246685 @default.
- W1986288210 cites W1619710608 @default.
- W1986288210 cites W1638078791 @default.
- W1986288210 cites W1645442091 @default.
- W1986288210 cites W1704732331 @default.
- W1986288210 cites W1784563469 @default.
- W1986288210 cites W1807866759 @default.
- W1986288210 cites W1820795132 @default.
- W1986288210 cites W1879803811 @default.
- W1986288210 cites W1884098294 @default.
- W1986288210 cites W1928837524 @default.
- W1986288210 cites W19613485 @default.
- W1986288210 cites W1963767682 @default.
- W1986288210 cites W1964131407 @default.
- W1986288210 cites W1966003712 @default.
- W1986288210 cites W1966382960 @default.
- W1986288210 cites W1967261289 @default.
- W1986288210 cites W1967281455 @default.
- W1986288210 cites W1969305530 @default.
- W1986288210 cites W1969768014 @default.
- W1986288210 cites W1970302367 @default.
- W1986288210 cites W1970606114 @default.
- W1986288210 cites W1970866544 @default.
- W1986288210 cites W1973281870 @default.
- W1986288210 cites W1974351951 @default.
- W1986288210 cites W1974443289 @default.
- W1986288210 cites W1976858067 @default.
- W1986288210 cites W1977267085 @default.
- W1986288210 cites W1977612821 @default.
- W1986288210 cites W1977614131 @default.
- W1986288210 cites W1977757584 @default.
- W1986288210 cites W1978483616 @default.
- W1986288210 cites W1978523429 @default.
- W1986288210 cites W1978525961 @default.
- W1986288210 cites W1978757999 @default.
- W1986288210 cites W1978959047 @default.
- W1986288210 cites W1979425342 @default.
- W1986288210 cites W1979575360 @default.
- W1986288210 cites W1979590358 @default.
- W1986288210 cites W1980190053 @default.
- W1986288210 cites W1981275924 @default.
- W1986288210 cites W1981580199 @default.
- W1986288210 cites W1982013273 @default.
- W1986288210 cites W1983292653 @default.
- W1986288210 cites W1984323936 @default.
- W1986288210 cites W1984344104 @default.
- W1986288210 cites W1984542187 @default.
- W1986288210 cites W1985315884 @default.
- W1986288210 cites W1985476822 @default.
- W1986288210 cites W1985681022 @default.
- W1986288210 cites W1986129155 @default.
- W1986288210 cites W1986451678 @default.
- W1986288210 cites W1986735189 @default.
- W1986288210 cites W1987076740 @default.
- W1986288210 cites W1987268193 @default.
- W1986288210 cites W1988075691 @default.
- W1986288210 cites W1988163014 @default.
- W1986288210 cites W1989150559 @default.
- W1986288210 cites W1989989032 @default.
- W1986288210 cites W1990438740 @default.
- W1986288210 cites W1991424179 @default.