FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986291810> ?p ?o ?g. }

• W1986291810 endingPage "e7" @default.
• W1986291810 startingPage "e1" @default.
• W1986291810 abstract "Introduction Predicting thrombosis in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibodies (aPL) is still challenging. Our objective was to determine risk factors for thrombotic events including activated protein C (APC) resistance proven by a thrombin generation (TG) assay in patients with SLE and/or aPL. Materials and methods We performed a prospective cohort study in a French University Hospital and tertiary care center. Ninety-two consecutive patients with SLE and/or aPL without ongoing anticoagulant treatment were enrolled. The outcome was time to thrombotic event. We evaluated clinical and laboratory variables including APC sensitivity ratio (APCsr) determined by TG. An APCsr > 90th percentile of a control population indicated APC resistance. Results Patients were followed-up for a median duration of 35 months (inter-quartile range: 26 to 62; 320 patient-years). Thrombosis during follow-up occurred in 18 patients. In univariate analysis, together with history of hypertension, superficial vein thrombosis (SVT) and arterial thrombosis, patients with both aPL and APC resistance had an increased risk for incident thromboembolic events (HR, 3.67[95% confidence interval, 1.31 to 10.31]). In multivariate analysis, only history of hypertension (HR, 10.77 [95% confidence interval, 3.15 to 36.83]), SVT (HR, 7.45 [95% confidence interval, 2.25 to 24.66]) and arterial thrombosis (HR, 3.31 [95% confidence interval, 1.14 to 9.55]) remained independent risk factors. Conclusions History of thrombosis including seemingly benign SVT have a higher predictive value for incident thrombotic events in SLE or aPL patients than APC resistance proven by TG." @default.
• W1986291810 created "2016-06-24" @default.
• W1986291810 creator A5002166266 @default.
• W1986291810 creator A5005178337 @default.
• W1986291810 creator A5005965718 @default.
• W1986291810 creator A5011032179 @default.
• W1986291810 creator A5052193063 @default.
• W1986291810 creator A5080173068 @default.
• W1986291810 creator A5089541378 @default.
• W1986291810 date "2013-07-01" @default.
• W1986291810 modified "2023-10-16" @default.
• W1986291810 title "Superficial vein thrombosis, thrombin generation and activated protein C resistance as predictors of thromboembolic events in lupus and antiphospholipid patients. A prospective cohort study" @default.
• W1986291810 cites W1491481195 @default.
• W1986291810 cites W1753491959 @default.
• W1986291810 cites W1837090086 @default.
• W1986291810 cites W1838320719 @default.
• W1986291810 cites W1927965016 @default.
• W1986291810 cites W1947708519 @default.
• W1986291810 cites W1975534632 @default.
• W1986291810 cites W1975668253 @default.
• W1986291810 cites W1980461685 @default.
• W1986291810 cites W1980784832 @default.
• W1986291810 cites W1991721757 @default.
• W1986291810 cites W1991899200 @default.
• W1986291810 cites W1993331725 @default.
• W1986291810 cites W2006666326 @default.
• W1986291810 cites W2010633868 @default.
• W1986291810 cites W2014860066 @default.
• W1986291810 cites W2023929943 @default.
• W1986291810 cites W2036314008 @default.
• W1986291810 cites W2036805409 @default.
• W1986291810 cites W2042958596 @default.
• W1986291810 cites W2044341259 @default.
• W1986291810 cites W2049939113 @default.
• W1986291810 cites W2050117403 @default.
• W1986291810 cites W2054330426 @default.
• W1986291810 cites W2069797332 @default.
• W1986291810 cites W2070527591 @default.
• W1986291810 cites W2077800201 @default.
• W1986291810 cites W2080536411 @default.
• W1986291810 cites W2080975717 @default.
• W1986291810 cites W2081165872 @default.
• W1986291810 cites W2092584114 @default.
• W1986291810 cites W2093720199 @default.
• W1986291810 cites W2116451043 @default.
• W1986291810 cites W2122755842 @default.
• W1986291810 cites W2125864147 @default.
• W1986291810 cites W2134407598 @default.
• W1986291810 cites W2146203649 @default.
• W1986291810 cites W2149323829 @default.
• W1986291810 cites W2153330445 @default.
• W1986291810 cites W2156950236 @default.
• W1986291810 cites W2157038471 @default.
• W1986291810 cites W2159913994 @default.
• W1986291810 cites W2163384287 @default.
• W1986291810 cites W2169170934 @default.
• W1986291810 cites W2181525513 @default.
• W1986291810 cites W2218406660 @default.
• W1986291810 cites W2327141264 @default.
• W1986291810 cites W2349457619 @default.
• W1986291810 cites W2612008267 @default.
• W1986291810 cites W2616490803 @default.
• W1986291810 cites W3092642076 @default.
• W1986291810 cites W4296981399 @default.
• W1986291810 doi "https://doi.org/10.1016/j.thromres.2013.04.012" @default.
• W1986291810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23676348" @default.
• W1986291810 hasPublicationYear "2013" @default.
• W1986291810 type Work @default.
• W1986291810 sameAs 1986291810 @default.
• W1986291810 citedByCount "31" @default.
• W1986291810 countsByYear W19862918102014 @default.
• W1986291810 countsByYear W19862918102015 @default.
• W1986291810 countsByYear W19862918102016 @default.
• W1986291810 countsByYear W19862918102017 @default.
• W1986291810 countsByYear W19862918102018 @default.
• W1986291810 countsByYear W19862918102019 @default.
• W1986291810 countsByYear W19862918102020 @default.
• W1986291810 countsByYear W19862918102021 @default.
• W1986291810 countsByYear W19862918102022 @default.
• W1986291810 countsByYear W19862918102023 @default.
• W1986291810 crossrefType "journal-article" @default.
• W1986291810 hasAuthorship W1986291810A5002166266 @default.
• W1986291810 hasAuthorship W1986291810A5005178337 @default.
• W1986291810 hasAuthorship W1986291810A5005965718 @default.
• W1986291810 hasAuthorship W1986291810A5011032179 @default.
• W1986291810 hasAuthorship W1986291810A5052193063 @default.
• W1986291810 hasAuthorship W1986291810A5080173068 @default.
• W1986291810 hasAuthorship W1986291810A5089541378 @default.
• W1986291810 hasConcept C126322002 @default.
• W1986291810 hasConcept C141071460 @default.
• W1986291810 hasConcept C144301174 @default.
• W1986291810 hasConcept C188816634 @default.
• W1986291810 hasConcept C2776874634 @default.
• W1986291810 hasConcept C2777175894 @default.
• W1986291810 hasConcept C2779956388 @default.
• W1986291810 hasConcept C2780011451 @default.
• W1986291810 hasConcept C2780022809 @default.
• W1986291810 hasConcept C2780868729 @default.

• next