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• W1986308419 endingPage "76" @default.
• W1986308419 startingPage "69" @default.
• W1986308419 abstract "The natriuretic peptide (NP) family is a group of peptides involved in cardiovascular and body fluid regulation in vertebrates. While only C-type NP (CNP) has been found in elasmobranchs, atrial NP (ANP), B-type NP (BNP) and CNP have been found in mammals, and ventricular NP (VNP) instead of BNP in teleosts. Thus, it was once hypothesized that CNP is the ancestral NP, from which ANP and BNP/VNP were generated. However, the discovery of hfNP in the hagfish, and CNP in the lamprey suggested that the ancestral NP had characteristics common to these two peptides. Genomic studies in ray-finned fish revealed multiplication processes of NP genes: The ancestral gene was duplicated into four CNP genes before the divergence of elasmobranchs, and ANP, BNP and VNP genes were generated from one of the four CNP genes by tandem duplications. From up to seven NP genes thus generated, tetrapods are supposed to have lost some of them. Concerning NP receptors, teleosts also have more subtypes (three guanylyl cyclase-coupled receptors and two clearance receptors) than mammals. It is of interest to examine how the complicated NP system in teleosts compared with tetrapods, is involved in the adaptation to a wide variety of osmotic environments." @default.
• W1986308419 created "2016-06-24" @default.
• W1986308419 creator A5007801419 @default.
• W1986308419 creator A5040646045 @default.
• W1986308419 date "2006-03-01" @default.
• W1986308419 modified "2023-10-15" @default.
• W1986308419 title "Molecular evolution of the natriuretic peptide system as revealed by comparative genomics" @default.
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• W1986308419 doi "https://doi.org/10.1016/j.cbd.2005.10.002" @default.
• W1986308419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20483236" @default.
• W1986308419 hasPublicationYear "2006" @default.
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