FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986345496> ?p ?o ?g. }

• W1986345496 endingPage "e50728" @default.
• W1986345496 startingPage "e50728" @default.
• W1986345496 abstract "Immune changes occurring after primary HIV infection (PHI) have a pivotal relevance. Our objective was to characterize the polyfunctionality of immune response triggered by PHI, and to characterize immune activation and regulatory T cells, correlating such features to disease progression.We followed 11 patients experiencing PHI for 4 years. By polychromatic flow cytometry, we studied every month, for the first 6 months, T lymphocyte polyfunctionality after cell stimulation with peptides derived from HIV-1 gag and nef. Tregs were identified by flow cytometry, and T cell activation studied by CD38 and HLA-DR expression.An increase of anti-gag and anti-nef CD8+ specific T cells was observed 3 months after PHI; however, truly polyfunctional T cells, also able to produce IL-2, were never found. No gross changes in Tregs were present. T lymphocyte activation was maximal 1 and 2 months after PHI, and significantly decreased in the following period. The level of activation two months after PHI was strictly correlated to the plasma viral load 1 year after infection, and significantly influenced the length of period without therapy. Indeed, 80% of patients with less than the median value of activated CD8+ (15.5%) or CD4+ (0.9%) T cells remained free of therapy for >46 months, while all patients over the median value had to start treatment within 26 months.T cell activation after PHI, more than T cell polyfunctionality or Tregs, is a predictive marker for the control of viral load and for the time required to start treatment." @default.
• W1986345496 created "2016-06-24" @default.
• W1986345496 creator A5011006690 @default.
• W1986345496 creator A5018307013 @default.
• W1986345496 creator A5025507520 @default.
• W1986345496 creator A5031185527 @default.
• W1986345496 creator A5045159459 @default.
• W1986345496 creator A5053175153 @default.
• W1986345496 creator A5053444531 @default.
• W1986345496 creator A5053930257 @default.
• W1986345496 creator A5054757201 @default.
• W1986345496 creator A5060149923 @default.
• W1986345496 creator A5060266180 @default.
• W1986345496 creator A5061140872 @default.
• W1986345496 creator A5082570595 @default.
• W1986345496 creator A5083279701 @default.
• W1986345496 creator A5090901960 @default.
• W1986345496 date "2012-12-07" @default.
• W1986345496 modified "2023-10-11" @default.
• W1986345496 title "T Cell Activation but Not Polyfunctionality after Primary HIV Infection Predicts Control of Viral Load and Length of the Time without Therapy" @default.
• W1986345496 cites W150683224 @default.
• W1986345496 cites W1655510925 @default.
• W1986345496 cites W1801247541 @default.
• W1986345496 cites W1964728054 @default.
• W1986345496 cites W1965031244 @default.
• W1986345496 cites W1990388100 @default.
• W1986345496 cites W1992672611 @default.
• W1986345496 cites W2001662765 @default.
• W1986345496 cites W2002285414 @default.
• W1986345496 cites W2003412654 @default.
• W1986345496 cites W2005227771 @default.
• W1986345496 cites W2011604576 @default.
• W1986345496 cites W2016987589 @default.
• W1986345496 cites W2020235727 @default.
• W1986345496 cites W2020568299 @default.
• W1986345496 cites W2022408626 @default.
• W1986345496 cites W2022831325 @default.
• W1986345496 cites W2025481552 @default.
• W1986345496 cites W2039797801 @default.
• W1986345496 cites W2047252585 @default.
• W1986345496 cites W2057148652 @default.
• W1986345496 cites W2057736537 @default.
• W1986345496 cites W2063738824 @default.
• W1986345496 cites W2068200417 @default.
• W1986345496 cites W2068517544 @default.
• W1986345496 cites W2082833306 @default.
• W1986345496 cites W2090549085 @default.
• W1986345496 cites W2103033611 @default.
• W1986345496 cites W2103182811 @default.
• W1986345496 cites W2115180633 @default.
• W1986345496 cites W2117553644 @default.
• W1986345496 cites W2125072873 @default.
• W1986345496 cites W2126141460 @default.
• W1986345496 cites W2127031590 @default.
• W1986345496 cites W2129114331 @default.
• W1986345496 cites W2132845032 @default.
• W1986345496 cites W2134219545 @default.
• W1986345496 cites W2135698322 @default.
• W1986345496 cites W2144365496 @default.
• W1986345496 cites W2149492547 @default.
• W1986345496 cites W2150484278 @default.
• W1986345496 cites W2160925670 @default.
• W1986345496 cites W2162457545 @default.
• W1986345496 cites W2166122762 @default.
• W1986345496 cites W2166653928 @default.
• W1986345496 cites W2323778070 @default.
• W1986345496 cites W4235464062 @default.
• W1986345496 doi "https://doi.org/10.1371/journal.pone.0050728" @default.
• W1986345496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3517542" @default.
• W1986345496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23236388" @default.
• W1986345496 hasPublicationYear "2012" @default.
• W1986345496 type Work @default.
• W1986345496 sameAs 1986345496 @default.
• W1986345496 citedByCount "20" @default.
• W1986345496 countsByYear W19863454962013 @default.
• W1986345496 countsByYear W19863454962014 @default.
• W1986345496 countsByYear W19863454962015 @default.
• W1986345496 countsByYear W19863454962016 @default.
• W1986345496 countsByYear W19863454962019 @default.
• W1986345496 countsByYear W19863454962020 @default.
• W1986345496 countsByYear W19863454962022 @default.
• W1986345496 crossrefType "journal-article" @default.
• W1986345496 hasAuthorship W1986345496A5011006690 @default.
• W1986345496 hasAuthorship W1986345496A5018307013 @default.
• W1986345496 hasAuthorship W1986345496A5025507520 @default.
• W1986345496 hasAuthorship W1986345496A5031185527 @default.
• W1986345496 hasAuthorship W1986345496A5045159459 @default.
• W1986345496 hasAuthorship W1986345496A5053175153 @default.
• W1986345496 hasAuthorship W1986345496A5053444531 @default.
• W1986345496 hasAuthorship W1986345496A5053930257 @default.
• W1986345496 hasAuthorship W1986345496A5054757201 @default.
• W1986345496 hasAuthorship W1986345496A5060149923 @default.
• W1986345496 hasAuthorship W1986345496A5060266180 @default.
• W1986345496 hasAuthorship W1986345496A5061140872 @default.
• W1986345496 hasAuthorship W1986345496A5082570595 @default.
• W1986345496 hasAuthorship W1986345496A5083279701 @default.
• W1986345496 hasAuthorship W1986345496A5090901960 @default.
• W1986345496 hasBestOaLocation W19863454961 @default.

• next