Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986365787> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1986365787 endingPage "2116" @default.
- W1986365787 startingPage "2112" @default.
- W1986365787 abstract "We investigated the effects of the well-known mutagenic agents ethyl methanesulfonate (EtMes), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), and ICR-191 on colonies of the Chinese hamster ovary line CHO cultured on a semisolid substrate. These agents induced heterogeneity in diameter and integrated optical density of colonies as determined by computer-assisted photography and subsequent analysis of the images of the colonies. When CHO colonies were exposed to agents such as urethane that are not known to be mutagenic in mammalian systems or to activation-requiring mutagens such as cyclophosphamide, there was no noticeable effect on the distribution of colony diameter and volume. Similarly, nonmutagenic agents such as dimethyl sulfoxide (Me2SO) also did not induce heterogeneity in colony diameter and integrated optical density. Our observations recommend the use of agar-grown mammalian cell colonies for predictive testing of chemical mutagens and carcinogens in a simple, in vitro mammalian cell assay. This assay system, unlike other mammalian cell culture assays, allows detection and measurement of the simultaneous effects of chemical mutagens on several genetic and non-genetic targets and, thus, may emulate more closely the potential hazards of these agents in vivo." @default.
- W1986365787 created "2016-06-24" @default.
- W1986365787 creator A5011724078 @default.
- W1986365787 creator A5069464048 @default.
- W1986365787 date "1984-04-01" @default.
- W1986365787 modified "2023-10-18" @default.
- W1986365787 title "A mutagen-testing assay based on heterogeneity in diameter and integrated optical density of mammalian cell colonies." @default.
- W1986365787 cites W1491249237 @default.
- W1986365787 cites W1881332839 @default.
- W1986365787 cites W1953011360 @default.
- W1986365787 cites W1973195696 @default.
- W1986365787 cites W2016097062 @default.
- W1986365787 cites W2027716659 @default.
- W1986365787 cites W2045659769 @default.
- W1986365787 cites W2046090752 @default.
- W1986365787 cites W2051232231 @default.
- W1986365787 cites W2057852373 @default.
- W1986365787 cites W2060917949 @default.
- W1986365787 cites W2087186171 @default.
- W1986365787 cites W2088809293 @default.
- W1986365787 cites W2090289780 @default.
- W1986365787 cites W2396718702 @default.
- W1986365787 cites W1638948223 @default.
- W1986365787 doi "https://doi.org/10.1073/pnas.81.7.2112" @default.
- W1986365787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/345447" @default.
- W1986365787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6585791" @default.
- W1986365787 hasPublicationYear "1984" @default.
- W1986365787 type Work @default.
- W1986365787 sameAs 1986365787 @default.
- W1986365787 citedByCount "5" @default.
- W1986365787 crossrefType "journal-article" @default.
- W1986365787 hasAuthorship W1986365787A5011724078 @default.
- W1986365787 hasAuthorship W1986365787A5069464048 @default.
- W1986365787 hasBestOaLocation W19863657872 @default.
- W1986365787 hasConcept C104317684 @default.
- W1986365787 hasConcept C114246631 @default.
- W1986365787 hasConcept C143425029 @default.
- W1986365787 hasConcept C153911025 @default.
- W1986365787 hasConcept C175656101 @default.
- W1986365787 hasConcept C178790620 @default.
- W1986365787 hasConcept C185592680 @default.
- W1986365787 hasConcept C207001950 @default.
- W1986365787 hasConcept C2776639595 @default.
- W1986365787 hasConcept C2776900477 @default.
- W1986365787 hasConcept C2778452553 @default.
- W1986365787 hasConcept C2778575167 @default.
- W1986365787 hasConcept C2779115727 @default.
- W1986365787 hasConcept C2780625556 @default.
- W1986365787 hasConcept C501734568 @default.
- W1986365787 hasConcept C54355233 @default.
- W1986365787 hasConcept C552990157 @default.
- W1986365787 hasConcept C55493867 @default.
- W1986365787 hasConcept C81885089 @default.
- W1986365787 hasConcept C86803240 @default.
- W1986365787 hasConceptScore W1986365787C104317684 @default.
- W1986365787 hasConceptScore W1986365787C114246631 @default.
- W1986365787 hasConceptScore W1986365787C143425029 @default.
- W1986365787 hasConceptScore W1986365787C153911025 @default.
- W1986365787 hasConceptScore W1986365787C175656101 @default.
- W1986365787 hasConceptScore W1986365787C178790620 @default.
- W1986365787 hasConceptScore W1986365787C185592680 @default.
- W1986365787 hasConceptScore W1986365787C207001950 @default.
- W1986365787 hasConceptScore W1986365787C2776639595 @default.
- W1986365787 hasConceptScore W1986365787C2776900477 @default.
- W1986365787 hasConceptScore W1986365787C2778452553 @default.
- W1986365787 hasConceptScore W1986365787C2778575167 @default.
- W1986365787 hasConceptScore W1986365787C2779115727 @default.
- W1986365787 hasConceptScore W1986365787C2780625556 @default.
- W1986365787 hasConceptScore W1986365787C501734568 @default.
- W1986365787 hasConceptScore W1986365787C54355233 @default.
- W1986365787 hasConceptScore W1986365787C552990157 @default.
- W1986365787 hasConceptScore W1986365787C55493867 @default.
- W1986365787 hasConceptScore W1986365787C81885089 @default.
- W1986365787 hasConceptScore W1986365787C86803240 @default.
- W1986365787 hasIssue "7" @default.
- W1986365787 hasLocation W19863657871 @default.
- W1986365787 hasLocation W19863657872 @default.
- W1986365787 hasLocation W19863657873 @default.
- W1986365787 hasLocation W19863657874 @default.
- W1986365787 hasOpenAccess W1986365787 @default.
- W1986365787 hasPrimaryLocation W19863657871 @default.
- W1986365787 hasRelatedWork W1806359922 @default.
- W1986365787 hasRelatedWork W1984984056 @default.
- W1986365787 hasRelatedWork W1986365787 @default.
- W1986365787 hasRelatedWork W2001479744 @default.
- W1986365787 hasRelatedWork W2044993475 @default.
- W1986365787 hasRelatedWork W2068888202 @default.
- W1986365787 hasRelatedWork W2100359584 @default.
- W1986365787 hasRelatedWork W2152638644 @default.
- W1986365787 hasRelatedWork W2428033975 @default.
- W1986365787 hasRelatedWork W2113941577 @default.
- W1986365787 hasVolume "81" @default.
- W1986365787 isParatext "false" @default.
- W1986365787 isRetracted "false" @default.
- W1986365787 magId "1986365787" @default.
- W1986365787 workType "article" @default.