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- W1986366930 abstract "2,3:18,19-Dioxidosqualene (3) was synthesized and isolated as a diastereomeric mixture. Incubation of 2,3-oxidosqualene with rat liver microsomes in the presence of dioxide 3 caused a high inhibition of lanosterol production (Ki=0.11 μM). The kinetic data showed that this inhibition was non-competitive." @default.
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- W1986366930 date "1992-10-01" @default.
- W1986366930 modified "2023-10-18" @default.
- W1986366930 title "2,3:18,19-dioxidosqualene: synthesis and activity as a potent inhibitor of 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomes" @default.
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- W1986366930 doi "https://doi.org/10.1016/s0960-894x(00)80221-8" @default.
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