Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986371300> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1986371300 endingPage "e285" @default.
- W1986371300 startingPage "e285" @default.
- W1986371300 abstract "Background: Whilst reports on the use of 1% voriconazole eye drops in the management of ophthalmic fungal keratitis have been promising, the voriconazole concentrations achieved in the eye were not sufficiently high to treat all types of fungal keratitis. Higher concentration of voriconazole eye drops may be required. We investigated the topical application of 2% voriconazole solution for the management of ophthalmic mycoses. Methods: Voriconazole solution (2%) was prepared by reconstituting intravenous Vfend® with sterile water preserved with 0.01% benzalkonium chloride. In a prospective open label study, non-keratitis patients scheduled for elective anterior segment eye surgery were recruited to receive 2% voriconazole eye drops hourly, commencing 4 hours before surgery. Aqueous humour samples were removed during surgery and analysed by high-performance liquid chromatography. 2% voriconazole eye drops were concurrently stored and monitored for stability. Results: Fourteen patients participated in the study. Eight samples were analysed (six samples were insufficient for analysis). The mean (± standard deviation) voriconazole concentration was 1.51 ± 1.00 μg/mL, and the mean sampling time after last-dose was 1.39 h. No side effects were reported by patients. The eye drops demonstrated excellent physical and chemical stability at refrigerated and room temperatures for at least 4 months. Conclusion: This is the first study to report on the topical application of 2% voriconazole eye drops. The eye drops appear to be safe, and the concentration of voriconazole achieved is adequate to treat most common fungal keratitis, and is similar to that reported in literature with the 1% solution administered with the same dosing frequency. This suggests that the penetration of voriconazole into the aqueous humour may not be concentration driven, at least through the intact infection-free cornea." @default.
- W1986371300 created "2016-06-24" @default.
- W1986371300 creator A5011551825 @default.
- W1986371300 creator A5013180301 @default.
- W1986371300 creator A5021535435 @default.
- W1986371300 creator A5022693852 @default.
- W1986371300 creator A5040184224 @default.
- W1986371300 creator A5045137056 @default.
- W1986371300 creator A5057782869 @default.
- W1986371300 creator A5070735111 @default.
- W1986371300 creator A5074116076 @default.
- W1986371300 date "2008-12-01" @default.
- W1986371300 modified "2023-10-05" @default.
- W1986371300 title "2% Voriconazole Eye Drops for the Management of Ophthalmic Fungal Keratitis" @default.
- W1986371300 doi "https://doi.org/10.1016/j.ijid.2008.05.764" @default.
- W1986371300 hasPublicationYear "2008" @default.
- W1986371300 type Work @default.
- W1986371300 sameAs 1986371300 @default.
- W1986371300 citedByCount "1" @default.
- W1986371300 countsByYear W19863713002019 @default.
- W1986371300 crossrefType "journal-article" @default.
- W1986371300 hasAuthorship W1986371300A5011551825 @default.
- W1986371300 hasAuthorship W1986371300A5013180301 @default.
- W1986371300 hasAuthorship W1986371300A5021535435 @default.
- W1986371300 hasAuthorship W1986371300A5022693852 @default.
- W1986371300 hasAuthorship W1986371300A5040184224 @default.
- W1986371300 hasAuthorship W1986371300A5045137056 @default.
- W1986371300 hasAuthorship W1986371300A5057782869 @default.
- W1986371300 hasAuthorship W1986371300A5070735111 @default.
- W1986371300 hasAuthorship W1986371300A5074116076 @default.
- W1986371300 hasBestOaLocation W19863713001 @default.
- W1986371300 hasConcept C118487528 @default.
- W1986371300 hasConcept C119767625 @default.
- W1986371300 hasConcept C141071460 @default.
- W1986371300 hasConcept C142724271 @default.
- W1986371300 hasConcept C16005928 @default.
- W1986371300 hasConcept C2775919038 @default.
- W1986371300 hasConcept C2776079991 @default.
- W1986371300 hasConcept C2776882836 @default.
- W1986371300 hasConcept C2778560704 @default.
- W1986371300 hasConcept C2779548794 @default.
- W1986371300 hasConcept C2780690907 @default.
- W1986371300 hasConcept C2992234860 @default.
- W1986371300 hasConcept C42219234 @default.
- W1986371300 hasConcept C71924100 @default.
- W1986371300 hasConceptScore W1986371300C118487528 @default.
- W1986371300 hasConceptScore W1986371300C119767625 @default.
- W1986371300 hasConceptScore W1986371300C141071460 @default.
- W1986371300 hasConceptScore W1986371300C142724271 @default.
- W1986371300 hasConceptScore W1986371300C16005928 @default.
- W1986371300 hasConceptScore W1986371300C2775919038 @default.
- W1986371300 hasConceptScore W1986371300C2776079991 @default.
- W1986371300 hasConceptScore W1986371300C2776882836 @default.
- W1986371300 hasConceptScore W1986371300C2778560704 @default.
- W1986371300 hasConceptScore W1986371300C2779548794 @default.
- W1986371300 hasConceptScore W1986371300C2780690907 @default.
- W1986371300 hasConceptScore W1986371300C2992234860 @default.
- W1986371300 hasConceptScore W1986371300C42219234 @default.
- W1986371300 hasConceptScore W1986371300C71924100 @default.
- W1986371300 hasLocation W19863713001 @default.
- W1986371300 hasOpenAccess W1986371300 @default.
- W1986371300 hasPrimaryLocation W19863713001 @default.
- W1986371300 hasRelatedWork W1965590376 @default.
- W1986371300 hasRelatedWork W2099189534 @default.
- W1986371300 hasRelatedWork W2162773145 @default.
- W1986371300 hasRelatedWork W2170291581 @default.
- W1986371300 hasRelatedWork W2781216749 @default.
- W1986371300 hasRelatedWork W2886344656 @default.
- W1986371300 hasRelatedWork W2889451064 @default.
- W1986371300 hasRelatedWork W2980998483 @default.
- W1986371300 hasRelatedWork W4211007882 @default.
- W1986371300 hasRelatedWork W4226262782 @default.
- W1986371300 hasVolume "12" @default.
- W1986371300 isParatext "false" @default.
- W1986371300 isRetracted "false" @default.
- W1986371300 magId "1986371300" @default.
- W1986371300 workType "article" @default.