Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986385611> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1986385611 endingPage "S2" @default.
- W1986385611 startingPage "593" @default.
- W1986385611 abstract "The plasma membrane of polarised epithelial cells is characterised by two structurally and functionally different domains, the apical and basolateral domains. These domains contain distinct protein and lipid constituents that are sorted by specific signals to the correct surface domain [[1]Nelson WJ Regulation of cell surface polarity from bacteria to mammals.Science. 1992; 258: 948-955Crossref PubMed Scopus (172) Google Scholar]. The best characterised apical sorting signal is that of glycophosphatidylinositol (GPI) membrane anchors [[2]Lisanti MP Sargiacomo M Graeve L Saltiel A Rodriguez-Boulan E Polarized epithelial distribution of glycosyl phosphatidylinositol anchored proteins in a renal epithelial line.Proc Natl Acad Sci USA. 1998; 85: 9557-9561Crossref Scopus (284) Google Scholar], although N-linked glycans on some secreted proteins [[3]Scheiffele P Peranen J Simons K N-glycans as apical sorting signals in epithelial cells.Nature. 1995; 378: 96-98Crossref PubMed Scopus (408) Google Scholar] and O-linked glycans [[4]Yeaman C Le Gall AH Baldwin AN Monlauzeur L Le Bivic A Rodriguez-Boulan E The O-glycosylated stalk domain is required for apical sorting of neurotrophin receptors in polarized MDCK cells.J Cell Biol. 1997; 139: 929-940Crossref PubMed Scopus (242) Google Scholar] also function as apical sorting signals. In the latter cases, however, the underlying sorting mechanisms remain obscure. Here, we have analysed the role of O-glycosylation in the apical sorting of sucrase-isomaltase (SI), a highly polarised N- and O-glycosylated intestinal enzyme, and the mechanisms underlying this process. Inhibition of O-glycosylation by benzyl-N-acetyl-α-D-galactosaminide (benzyl-GalNAc) was accompanied by a dramatic shift in the sorting of SI from the apical membrane to both membranes. The sorting mechanism of SI involves its association with sphingolipid- and cholesterol-rich membrane rafts because this association was eliminated when O-glycosylation was inhibited by benzyl-GaINAc. The results demonstrate for the first time that O-linked glycans mediate apical sorting through association with lipid rafts." @default.
- W1986385611 created "2016-06-24" @default.
- W1986385611 creator A5001086890 @default.
- W1986385611 creator A5034476412 @default.
- W1986385611 creator A5044873395 @default.
- W1986385611 creator A5068130365 @default.
- W1986385611 creator A5080291393 @default.
- W1986385611 creator A5086375708 @default.
- W1986385611 date "1999-06-01" @default.
- W1986385611 modified "2023-10-17" @default.
- W1986385611 title "O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts" @default.
- W1986385611 cites W1535433473 @default.
- W1986385611 cites W1651616001 @default.
- W1986385611 cites W1757503351 @default.
- W1986385611 cites W1887452217 @default.
- W1986385611 cites W1964117622 @default.
- W1986385611 cites W1964235448 @default.
- W1986385611 cites W1966551225 @default.
- W1986385611 cites W1999203970 @default.
- W1986385611 cites W2030662833 @default.
- W1986385611 cites W2079420925 @default.
- W1986385611 cites W2087568656 @default.
- W1986385611 cites W2096744480 @default.
- W1986385611 cites W2115945894 @default.
- W1986385611 cites W2121936687 @default.
- W1986385611 cites W2122359837 @default.
- W1986385611 cites W2401092081 @default.
- W1986385611 doi "https://doi.org/10.1016/s0960-9822(99)80263-2" @default.
- W1986385611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359703" @default.
- W1986385611 hasPublicationYear "1999" @default.
- W1986385611 type Work @default.
- W1986385611 sameAs 1986385611 @default.
- W1986385611 citedByCount "156" @default.
- W1986385611 countsByYear W19863856112012 @default.
- W1986385611 countsByYear W19863856112013 @default.
- W1986385611 countsByYear W19863856112014 @default.
- W1986385611 countsByYear W19863856112015 @default.
- W1986385611 countsByYear W19863856112016 @default.
- W1986385611 countsByYear W19863856112017 @default.
- W1986385611 countsByYear W19863856112018 @default.
- W1986385611 countsByYear W19863856112019 @default.
- W1986385611 countsByYear W19863856112020 @default.
- W1986385611 countsByYear W19863856112021 @default.
- W1986385611 countsByYear W19863856112023 @default.
- W1986385611 crossrefType "journal-article" @default.
- W1986385611 hasAuthorship W1986385611A5001086890 @default.
- W1986385611 hasAuthorship W1986385611A5034476412 @default.
- W1986385611 hasAuthorship W1986385611A5044873395 @default.
- W1986385611 hasAuthorship W1986385611A5068130365 @default.
- W1986385611 hasAuthorship W1986385611A5080291393 @default.
- W1986385611 hasAuthorship W1986385611A5086375708 @default.
- W1986385611 hasBestOaLocation W19863856111 @default.
- W1986385611 hasConcept C108625454 @default.
- W1986385611 hasConcept C1491633281 @default.
- W1986385611 hasConcept C176080148 @default.
- W1986385611 hasConcept C206212055 @default.
- W1986385611 hasConcept C2777313579 @default.
- W1986385611 hasConcept C3018436504 @default.
- W1986385611 hasConcept C41625074 @default.
- W1986385611 hasConcept C55493867 @default.
- W1986385611 hasConcept C62478195 @default.
- W1986385611 hasConcept C79266657 @default.
- W1986385611 hasConcept C86803240 @default.
- W1986385611 hasConcept C95444343 @default.
- W1986385611 hasConceptScore W1986385611C108625454 @default.
- W1986385611 hasConceptScore W1986385611C1491633281 @default.
- W1986385611 hasConceptScore W1986385611C176080148 @default.
- W1986385611 hasConceptScore W1986385611C206212055 @default.
- W1986385611 hasConceptScore W1986385611C2777313579 @default.
- W1986385611 hasConceptScore W1986385611C3018436504 @default.
- W1986385611 hasConceptScore W1986385611C41625074 @default.
- W1986385611 hasConceptScore W1986385611C55493867 @default.
- W1986385611 hasConceptScore W1986385611C62478195 @default.
- W1986385611 hasConceptScore W1986385611C79266657 @default.
- W1986385611 hasConceptScore W1986385611C86803240 @default.
- W1986385611 hasConceptScore W1986385611C95444343 @default.
- W1986385611 hasIssue "11" @default.
- W1986385611 hasLocation W19863856111 @default.
- W1986385611 hasLocation W19863856112 @default.
- W1986385611 hasOpenAccess W1986385611 @default.
- W1986385611 hasPrimaryLocation W19863856111 @default.
- W1986385611 hasRelatedWork W2006994535 @default.
- W1986385611 hasRelatedWork W2015887288 @default.
- W1986385611 hasRelatedWork W2021954858 @default.
- W1986385611 hasRelatedWork W2062502531 @default.
- W1986385611 hasRelatedWork W2142615856 @default.
- W1986385611 hasRelatedWork W2143686380 @default.
- W1986385611 hasRelatedWork W2341848569 @default.
- W1986385611 hasRelatedWork W2552897925 @default.
- W1986385611 hasRelatedWork W3038633766 @default.
- W1986385611 hasRelatedWork W3135687361 @default.
- W1986385611 hasVolume "9" @default.
- W1986385611 isParatext "false" @default.
- W1986385611 isRetracted "false" @default.
- W1986385611 magId "1986385611" @default.
- W1986385611 workType "article" @default.