Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986389670> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1986389670 endingPage "217" @default.
- W1986389670 startingPage "213" @default.
- W1986389670 abstract "Abstract Calmodulin (CaM) is a ubiquitous, calcium-binding protein that regulates several important aspects of cellular metabolism. A number of enzymes such as phosphodiesterase (PDE-1) are stimulated by CaM. In previous studies, our results showed that artemisinin (ART) is a potent inhibitor of CaM and PDE-1 activity. In this study, the effects of dihydroartemisinin (DHA) that is a semisynthesized agent from the ART on CaM structure were investigated. The result showed that DHA increased fluorescence emission of CaM in higher amounts compared with the ART. Also, the effect of DHA on CaM-dependent PDE-1 activity was studied. Kinetic analysis of the DHA–CaM interaction showed that this agent competitively inhibited the activation of PDE-1 without affecting Vmax. Km values of PDE-1 in the presence of ART and DHA were 10 and 15 µM, respectively; DHA increased Km value in higher amounts compared with the ART. The Ki constants for ART and DHA were 10 µM and 7.3 µM, respectively. As a conclusion, CaM and CaM-dependent PDE-1 were inhibited by DHA more than ART. The data indicated that DHA could stimulate the delayed type hypersensitivity (DTH) against sheep blood cells in Balb/c mice and reduced the tumor growth in vivo against invasive ductal carcinoma in Balb/c mice." @default.
- W1986389670 created "2016-06-24" @default.
- W1986389670 creator A5005583668 @default.
- W1986389670 creator A5031385125 @default.
- W1986389670 creator A5056040998 @default.
- W1986389670 creator A5063010036 @default.
- W1986389670 creator A5089937582 @default.
- W1986389670 date "2010-02-01" @default.
- W1986389670 modified "2023-09-25" @default.
- W1986389670 title "Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses" @default.
- W1986389670 cites W1608453530 @default.
- W1986389670 cites W1963728755 @default.
- W1986389670 cites W1964095666 @default.
- W1986389670 cites W1986397607 @default.
- W1986389670 cites W1989518640 @default.
- W1986389670 cites W1990501492 @default.
- W1986389670 cites W2010459983 @default.
- W1986389670 cites W2012068830 @default.
- W1986389670 cites W2018053695 @default.
- W1986389670 cites W2026790505 @default.
- W1986389670 cites W2036246796 @default.
- W1986389670 cites W2043421640 @default.
- W1986389670 cites W2054618296 @default.
- W1986389670 cites W2072966392 @default.
- W1986389670 cites W2073391946 @default.
- W1986389670 cites W2086770774 @default.
- W1986389670 cites W2166389885 @default.
- W1986389670 cites W2179930767 @default.
- W1986389670 cites W2329014917 @default.
- W1986389670 cites W4211158172 @default.
- W1986389670 doi "https://doi.org/10.1016/j.intimp.2009.11.002" @default.
- W1986389670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19900584" @default.
- W1986389670 hasPublicationYear "2010" @default.
- W1986389670 type Work @default.
- W1986389670 sameAs 1986389670 @default.
- W1986389670 citedByCount "16" @default.
- W1986389670 countsByYear W19863896702012 @default.
- W1986389670 countsByYear W19863896702013 @default.
- W1986389670 countsByYear W19863896702014 @default.
- W1986389670 countsByYear W19863896702015 @default.
- W1986389670 countsByYear W19863896702018 @default.
- W1986389670 countsByYear W19863896702019 @default.
- W1986389670 countsByYear W19863896702020 @default.
- W1986389670 countsByYear W19863896702022 @default.
- W1986389670 crossrefType "journal-article" @default.
- W1986389670 hasAuthorship W1986389670A5005583668 @default.
- W1986389670 hasAuthorship W1986389670A5031385125 @default.
- W1986389670 hasAuthorship W1986389670A5056040998 @default.
- W1986389670 hasAuthorship W1986389670A5063010036 @default.
- W1986389670 hasAuthorship W1986389670A5089937582 @default.
- W1986389670 hasConcept C181199279 @default.
- W1986389670 hasConcept C185592680 @default.
- W1986389670 hasConcept C203014093 @default.
- W1986389670 hasConcept C29688787 @default.
- W1986389670 hasConcept C55493867 @default.
- W1986389670 hasConcept C62826618 @default.
- W1986389670 hasConcept C86803240 @default.
- W1986389670 hasConcept C8891405 @default.
- W1986389670 hasConcept C95444343 @default.
- W1986389670 hasConcept C98274493 @default.
- W1986389670 hasConceptScore W1986389670C181199279 @default.
- W1986389670 hasConceptScore W1986389670C185592680 @default.
- W1986389670 hasConceptScore W1986389670C203014093 @default.
- W1986389670 hasConceptScore W1986389670C29688787 @default.
- W1986389670 hasConceptScore W1986389670C55493867 @default.
- W1986389670 hasConceptScore W1986389670C62826618 @default.
- W1986389670 hasConceptScore W1986389670C86803240 @default.
- W1986389670 hasConceptScore W1986389670C8891405 @default.
- W1986389670 hasConceptScore W1986389670C95444343 @default.
- W1986389670 hasConceptScore W1986389670C98274493 @default.
- W1986389670 hasIssue "2" @default.
- W1986389670 hasLocation W19863896701 @default.
- W1986389670 hasOpenAccess W1986389670 @default.
- W1986389670 hasPrimaryLocation W19863896701 @default.
- W1986389670 hasRelatedWork W1561729644 @default.
- W1986389670 hasRelatedWork W1979966414 @default.
- W1986389670 hasRelatedWork W2005494219 @default.
- W1986389670 hasRelatedWork W2008346915 @default.
- W1986389670 hasRelatedWork W2020325408 @default.
- W1986389670 hasRelatedWork W2040930963 @default.
- W1986389670 hasRelatedWork W2062740392 @default.
- W1986389670 hasRelatedWork W2082828222 @default.
- W1986389670 hasRelatedWork W2162756399 @default.
- W1986389670 hasRelatedWork W955179056 @default.
- W1986389670 hasVolume "10" @default.
- W1986389670 isParatext "false" @default.
- W1986389670 isRetracted "false" @default.
- W1986389670 magId "1986389670" @default.
- W1986389670 workType "article" @default.