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- W1986395280 abstract "Maxillary sinus floor augmentation with autogenous bone has become a widely accepted procedure in implant dentistry. The use of osteoconductive bone substitutes in this indication is controversial, since their use can lead to a prolonged healing time, inhomogenous ossification, foreign body reaction, migration of particles and low bone-implant contact (BIC). The purpose of this study was to examine whether the combination of an osteoinductive protein (recombinant human osteogenic protein-l (rhOP-1=bone morphogenetic protein-7) with natural bovine bone mineral (Bio-Oss®) would improve ossification and the bone-implant contact (BIC) in a sinus floor augmentation with simultaneous placement of implants. In this study, the maxillary sinus floors in 5 miniature pigs were augmented with 3 ml Bio-Oss® containing 420 μg rhOP-1 on the test side and 3 ml Bio-Oss® alone on the control side. At the time of augmentation a titanium implant (ITI®) was inserted from a laterocaudal direction. After 6 months of healing the sites of augmentation were removed and examined in non-decalcified sections by microradiography, fluorescence microscopy of sequentially labelled specimens and by histometry. On both sides, significant amounts of newly-formed bone were observed. However, on the test sites, the percentage of BIC in the augmented area was 80.0% versus 38.4% on control sites. It can be concluded that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone. Therefore recombinant human osteogenic protein-l delivered by natural bone mineral has the potential to become a clinical alternative for autogenous bone grafts in sinus floor augmentation." @default.
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- W1986395280 date "1999-12-01" @default.
- W1986395280 modified "2023-10-17" @default.
- W1986395280 title "Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-l. A histometric study in miniature pigs." @default.
- W1986395280 doi "https://doi.org/10.1034/j.1600-0501.1999.100609.x" @default.
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