FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986397768> ?p ?o ?g. }

• W1986397768 endingPage "1271" @default.
• W1986397768 startingPage "1262" @default.
• W1986397768 abstract "Context. Tephrosia toxicaria is currently known as Tephrosia sinapou (Buc'hoz) A. Chev. (Fabaceae) and is a source of compounds such as flavonoids that inhibit inflammatory pain.Objective: To investigate the analgesic effect and mechanisms of the ethyl acetate extract of T. sinapou in inflammatory pain in mice.Materials and methods: Behavioral responses were evaluated using mechanical (1–24 h) and thermal hyperalgesia (0.5–5 h), writhing response (20 min) and rota-rod (1–5 h) tests. Neutrophil recruitment (myeloperoxidase activity), cytokines (tumor necrosis factor [TNF]α and interleukin [IL]-1β), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels were determined by colorimetric assays. Pharmacological treatments were opioid receptor antagonist (naloxone, 0.1–1 mg/kg) and control opioid (morphine, 5 mg/kg). Inflammatory stimuli were carrageenin (100 µg/paw), complete Freund’s adjuvant (CFA, 10 µl/paw), prostaglandin E2 (PGE2, 100 ng/paw) and acetic acid (0.8%).Results: The intraperitoneal pre-treatment with extract inhibited in a dose-dependent (30–300 mg/kg) dependent manner the mechanical hyperalgesia induced by carrageenin (up to 93% inhibition). The post-treatment (100 mg/kg) inhibited CFA-induced hyperalgesia (up to 63% inhibition). Naloxone (1 mg/kg) prevented the inhibitory effect of the extract over carrageenin-induced mechanical (100%) and thermal (100%) hyperalgesia, neutrophil recruitment (52%) and TNFα (63%) and IL-1β (98%) production, thermal threshold in naïve mice (99%), PGE2-induced mechanical hyperalgesia (88%) and acetic acid-induced writhing response (49%). There was no significant alteration in the rota-rod test, and AST and ALT serum levels by extract treatment.Discussion and conclusion. Tephrosia sinapou ethyl acetate extract reduces inflammatory pain by activating an opioid receptor-dependent mechanism." @default.
• W1986397768 created "2016-06-24" @default.
• W1986397768 creator A5000213287 @default.
• W1986397768 creator A5039683667 @default.
• W1986397768 creator A5045126526 @default.
• W1986397768 creator A5055772038 @default.
• W1986397768 creator A5063282482 @default.
• W1986397768 creator A5064208545 @default.
• W1986397768 creator A5065925401 @default.
• W1986397768 creator A5072173086 @default.
• W1986397768 creator A5078024039 @default.
• W1986397768 creator A5089750280 @default.
• W1986397768 date "2013-07-16" @default.
• W1986397768 modified "2023-10-16" @default.
• W1986397768 title "Tephrosia sinapouethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFαand IL-1βproduction" @default.
• W1986397768 cites W1488006211 @default.
• W1986397768 cites W1547774099 @default.
• W1986397768 cites W1961542776 @default.
• W1986397768 cites W1972775390 @default.
• W1986397768 cites W1978939719 @default.
• W1986397768 cites W1983393601 @default.
• W1986397768 cites W1986696886 @default.
• W1986397768 cites W1990212128 @default.
• W1986397768 cites W1990882591 @default.
• W1986397768 cites W2000983477 @default.
• W1986397768 cites W2003973282 @default.
• W1986397768 cites W2006612420 @default.
• W1986397768 cites W2007755013 @default.
• W1986397768 cites W2012168857 @default.
• W1986397768 cites W2019782809 @default.
• W1986397768 cites W2026195388 @default.
• W1986397768 cites W2027346881 @default.
• W1986397768 cites W2027617862 @default.
• W1986397768 cites W2031468866 @default.
• W1986397768 cites W2032683573 @default.
• W1986397768 cites W2039303620 @default.
• W1986397768 cites W2042732072 @default.
• W1986397768 cites W2042873838 @default.
• W1986397768 cites W2047553141 @default.
• W1986397768 cites W2055093766 @default.
• W1986397768 cites W2057196011 @default.
• W1986397768 cites W2059035026 @default.
• W1986397768 cites W2060798263 @default.
• W1986397768 cites W2065432788 @default.
• W1986397768 cites W2066334362 @default.
• W1986397768 cites W2068707948 @default.
• W1986397768 cites W2072901945 @default.
• W1986397768 cites W2074192779 @default.
• W1986397768 cites W2076951089 @default.
• W1986397768 cites W2077305107 @default.
• W1986397768 cites W2078278102 @default.
• W1986397768 cites W2078403452 @default.
• W1986397768 cites W2081200584 @default.
• W1986397768 cites W2087454739 @default.
• W1986397768 cites W2088584036 @default.
• W1986397768 cites W2094095752 @default.
• W1986397768 cites W2107610513 @default.
• W1986397768 cites W2110063773 @default.
• W1986397768 cites W2113530784 @default.
• W1986397768 cites W2115158780 @default.
• W1986397768 cites W2130955850 @default.
• W1986397768 cites W2140310624 @default.
• W1986397768 cites W2159550967 @default.
• W1986397768 cites W2159752910 @default.
• W1986397768 cites W2164046878 @default.
• W1986397768 cites W2165170037 @default.
• W1986397768 cites W2169576250 @default.
• W1986397768 cites W2171223432 @default.
• W1986397768 doi "https://doi.org/10.3109/13880209.2013.786099" @default.
• W1986397768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23855752" @default.
• W1986397768 hasPublicationYear "2013" @default.
• W1986397768 type Work @default.
• W1986397768 sameAs 1986397768 @default.
• W1986397768 citedByCount "14" @default.
• W1986397768 countsByYear W19863977682014 @default.
• W1986397768 countsByYear W19863977682015 @default.
• W1986397768 countsByYear W19863977682016 @default.
• W1986397768 countsByYear W19863977682017 @default.
• W1986397768 countsByYear W19863977682018 @default.
• W1986397768 countsByYear W19863977682019 @default.
• W1986397768 countsByYear W19863977682020 @default.
• W1986397768 countsByYear W19863977682021 @default.
• W1986397768 crossrefType "journal-article" @default.
• W1986397768 hasAuthorship W1986397768A5000213287 @default.
• W1986397768 hasAuthorship W1986397768A5039683667 @default.
• W1986397768 hasAuthorship W1986397768A5045126526 @default.
• W1986397768 hasAuthorship W1986397768A5055772038 @default.
• W1986397768 hasAuthorship W1986397768A5063282482 @default.
• W1986397768 hasAuthorship W1986397768A5064208545 @default.
• W1986397768 hasAuthorship W1986397768A5065925401 @default.
• W1986397768 hasAuthorship W1986397768A5072173086 @default.
• W1986397768 hasAuthorship W1986397768A5078024039 @default.
• W1986397768 hasAuthorship W1986397768A5089750280 @default.
• W1986397768 hasConcept C126322002 @default.
• W1986397768 hasConcept C134018914 @default.
• W1986397768 hasConcept C15490471 @default.
• W1986397768 hasConcept C164027704 @default.
• W1986397768 hasConcept C170493617 @default.

• next