FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986408025> ?p ?o ?g. }

• W1986408025 endingPage "2330" @default.
• W1986408025 startingPage "2317" @default.
• W1986408025 abstract "High-frequency intake and high drug-induced seeking are associated with cocaine addiction in both human and animals. However, their relationships and neurobiological underpinnings remain hypothetical. The medial prefrontal cortex (mPFC), basolateral amygdala (BLA), and nucleus accumbens (NAc) have been shown to have a role in cocaine seeking. However, their involvement in regulating high-frequency intake and high cocaine-induced seeking is unclear. We manipulated frequency of cocaine self-administration and investigated whether it influenced cocaine seeking. The contribution of the aforementioned structures was evaluated using changes in expression of the immediate early gene c-Fos and targeted optogenetic manipulations. Rats that self-administered at High frequency (short inter-infusion intervals allowed by short time-out) showed higher cocaine-induced seeking than low frequency rats (long inter-infusions intervals imposed by long time-out), as measured with cocaine-induced reinstatement. c-Fos was enhanced in High frequency rats in the prelimbic (PL) and infralimbic (IL) areas of the mPFC, the BLA, and the NAc core and shell. Correlational analysis of c-Fos revealed that the PL was a critical node strongly correlated with both the IL and NAc core in High frequency rats. Targeted optogenetic inactivation of the PL decreased cocaine-induced reinstatement, but increased cocaine self-administration, in High frequency rats. In contrast, optogenetic activation of the PL had no effect on Low frequency rats. Thus, high-frequency intake promotes a PL-dependent control of cocaine seeking, with the PL exerting a facilitatory or inhibitory effect, depending on operant contingencies. Individual differences in cocaine-induced PL activation might be a source of vulnerability for poorly controlled cocaine-induced seeking and/or cocaine intake." @default.
• W1986408025 created "2016-06-24" @default.
• W1986408025 creator A5001353231 @default.
• W1986408025 creator A5008147980 @default.
• W1986408025 creator A5017413763 @default.
• W1986408025 creator A5025599568 @default.
• W1986408025 creator A5031355779 @default.
• W1986408025 creator A5052409847 @default.
• W1986408025 creator A5066913111 @default.
• W1986408025 creator A5073325220 @default.
• W1986408025 creator A5077661893 @default.
• W1986408025 date "2014-03-17" @default.
• W1986408025 modified "2023-10-14" @default.
• W1986408025 title "Frequency of Cocaine Self-Administration Influences Drug Seeking in the Rat: Optogenetic Evidence for a Role of the Prelimbic Cortex" @default.
• W1986408025 cites W133897333 @default.
• W1986408025 cites W1694031258 @default.
• W1986408025 cites W1889428062 @default.
• W1986408025 cites W1922497758 @default.
• W1986408025 cites W1962727914 @default.
• W1986408025 cites W1970238016 @default.
• W1986408025 cites W1978686840 @default.
• W1986408025 cites W1980321165 @default.
• W1986408025 cites W1981245258 @default.
• W1986408025 cites W1981514537 @default.
• W1986408025 cites W1982825786 @default.
• W1986408025 cites W1985243652 @default.
• W1986408025 cites W1990355775 @default.
• W1986408025 cites W2001281439 @default.
• W1986408025 cites W2001836305 @default.
• W1986408025 cites W2009740212 @default.
• W1986408025 cites W2013536737 @default.
• W1986408025 cites W2022391976 @default.
• W1986408025 cites W2040331319 @default.
• W1986408025 cites W2041457323 @default.
• W1986408025 cites W2044954624 @default.
• W1986408025 cites W2047831967 @default.
• W1986408025 cites W2048186734 @default.
• W1986408025 cites W2052155977 @default.
• W1986408025 cites W2059543761 @default.
• W1986408025 cites W2075427179 @default.
• W1986408025 cites W2078530990 @default.
• W1986408025 cites W2096902190 @default.
• W1986408025 cites W2097516070 @default.
• W1986408025 cites W2098532348 @default.
• W1986408025 cites W2098790905 @default.
• W1986408025 cites W2099527614 @default.
• W1986408025 cites W2112323466 @default.
• W1986408025 cites W2129962512 @default.
• W1986408025 cites W2140159910 @default.
• W1986408025 cites W2143057278 @default.
• W1986408025 cites W2149765291 @default.
• W1986408025 cites W2165106227 @default.
• W1986408025 cites W2169405285 @default.
• W1986408025 doi "https://doi.org/10.1038/npp.2014.66" @default.
• W1986408025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4138740" @default.
• W1986408025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24633559" @default.
• W1986408025 hasPublicationYear "2014" @default.
• W1986408025 type Work @default.
• W1986408025 sameAs 1986408025 @default.
• W1986408025 citedByCount "49" @default.
• W1986408025 countsByYear W19864080252014 @default.
• W1986408025 countsByYear W19864080252015 @default.
• W1986408025 countsByYear W19864080252016 @default.
• W1986408025 countsByYear W19864080252017 @default.
• W1986408025 countsByYear W19864080252018 @default.
• W1986408025 countsByYear W19864080252019 @default.
• W1986408025 countsByYear W19864080252020 @default.
• W1986408025 countsByYear W19864080252021 @default.
• W1986408025 countsByYear W19864080252022 @default.
• W1986408025 countsByYear W19864080252023 @default.
• W1986408025 crossrefType "journal-article" @default.
• W1986408025 hasAuthorship W1986408025A5001353231 @default.
• W1986408025 hasAuthorship W1986408025A5008147980 @default.
• W1986408025 hasAuthorship W1986408025A5017413763 @default.
• W1986408025 hasAuthorship W1986408025A5025599568 @default.
• W1986408025 hasAuthorship W1986408025A5031355779 @default.
• W1986408025 hasAuthorship W1986408025A5052409847 @default.
• W1986408025 hasAuthorship W1986408025A5066913111 @default.
• W1986408025 hasAuthorship W1986408025A5073325220 @default.
• W1986408025 hasAuthorship W1986408025A5077661893 @default.
• W1986408025 hasBestOaLocation W19864080251 @default.
• W1986408025 hasConcept C15744967 @default.
• W1986408025 hasConcept C169760540 @default.
• W1986408025 hasConcept C169900460 @default.
• W1986408025 hasConcept C2776552330 @default.
• W1986408025 hasConcept C2778555786 @default.
• W1986408025 hasConcept C2779144063 @default.
• W1986408025 hasConcept C2779934784 @default.
• W1986408025 hasConcept C2780451725 @default.
• W1986408025 hasConcept C2781195155 @default.
• W1986408025 hasConcept C48856860 @default.
• W1986408025 hasConcept C50738837 @default.
• W1986408025 hasConcept C513476851 @default.
• W1986408025 hasConcept C71924100 @default.
• W1986408025 hasConcept C98274493 @default.
• W1986408025 hasConceptScore W1986408025C15744967 @default.
• W1986408025 hasConceptScore W1986408025C169760540 @default.
• W1986408025 hasConceptScore W1986408025C169900460 @default.

• next