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• W1986408039 abstract "Our previous studies have indicated that sensory deprivation in the developing and mature nervous system could bring about an adjustment in oxidative metabolism of neurons demonstrable by cytochrome oxidase (C.O.) histochemistry45,46,49. Since sensory deprivation potentially involves changes in several parameters, such as natural stimuli, action potentials and axoplasmic transport, we wished to know if the cessation of primary afferent impulses could produce enzymatic adjustment in the postsynaptic neurons. Tetrodotoxin (TTX), in a dosage determined by Stryker (personal communication) to block action potentials without blocking axoplasmic transport, was injected intravitreally into one eye of 10 adult cats every 3 days for total periods of 1, 2, 4, 5.5 or 6 weeks respectively. After perfusion, the brains were processed for C.O. histochemistry. The results indicated that: (1) a decreased level of C.O. activity was observed in the lateral geniculate (LGN) laminae innervated by the injected eye as well as in area 17 of all animals; (2) changes were discernible after 1 week, which was the earliest time examined, but became progressively more prominent up to 6 weeks; (3) within the LGN, the ipsilateral lamina A1 consistently appeared more severely affected than the contralateral lamina A; (4) the monocular segment of the affected lamina A exhibited a high level of enzyme activity, indicating that its oxidative metabolism might be sustained by other factor(s) or synaptic activity; (5) within the binocular representation of the striate cortex, a banding pattern of high and low C.O. activity in lamina IV became progressively more prominent with longer survivals. In cats subjected to 4 weeks of TTX treatment and 6 weeks of recovery, the enzymatic levels in the affected LGN and cortical laminae were comparable to that of the normal. This indicated that the dosage used apparently did not damage the neural pathways. Thus, impulse blockage can cause a decrease in the level of cytochrome oxidase activity in the affected postsynaptic neurons, and the maintenance of functional and enzymatic integrity of postsynaptic neurons in the adult is dependent upon viable presynaptic impulse conduction." @default.
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• W1986408039 date "1983-02-01" @default.
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• W1986408039 title "The effect of impulse blockage on cytochrome oxidase activity in the cat visual system" @default.
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• W1986408039 doi "https://doi.org/10.1016/0006-8993(83)90622-4" @default.
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