Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986411547> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1986411547 endingPage "78" @default.
- W1986411547 startingPage "73" @default.
- W1986411547 abstract "The thymus is a central lymphoid organ, in which T cell precursors differentiate and generate most of the so-called T cell repertoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major and common feature observed in acute viral, bacterial and parasitic diseases, is a depletion of cortical thymocytes, mostly those bearing the CD4-CD8 double positive phenotype. This occurs simultaneously to the relative enrichment in medullary CD4 or CD8 single positive cells, expressing high densities of the CD3 complex. Additionally we noticed a variety of changes in the thymic microenvironment (and particularly its epithelial component), comprising abnormal location of thymic epithelial cell subsets as well has a denser Ia-bearing cellular network. Moreover, the extracellular matrix network was altered with an intralobular increase of basement membrane proteins that positively correlated with the degree of thymocyte death. Lastly, anti-thymic cell antibodies were detected in both human and animal models of infectious diseases, and in some of them a phenomenon of molecular mimicry could be evidenced. Taken together, the data reviewed herein clearly show that the thymus should be regarded as a target in infectious diseases." @default.
- W1986411547 created "2016-06-24" @default.
- W1986411547 creator A5008122330 @default.
- W1986411547 creator A5063166816 @default.
- W1986411547 creator A5067640386 @default.
- W1986411547 creator A5069208817 @default.
- W1986411547 creator A5080657027 @default.
- W1986411547 creator A5089215094 @default.
- W1986411547 date "1992-01-01" @default.
- W1986411547 modified "2023-09-27" @default.
- W1986411547 title "Is the thymus a target organ in infectious diseases?" @default.
- W1986411547 doi "https://doi.org/10.1590/s0074-02761992000900010" @default.
- W1986411547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1342720" @default.
- W1986411547 hasPublicationYear "1992" @default.
- W1986411547 type Work @default.
- W1986411547 sameAs 1986411547 @default.
- W1986411547 citedByCount "11" @default.
- W1986411547 countsByYear W19864115472021 @default.
- W1986411547 crossrefType "journal-article" @default.
- W1986411547 hasAuthorship W1986411547A5008122330 @default.
- W1986411547 hasAuthorship W1986411547A5063166816 @default.
- W1986411547 hasAuthorship W1986411547A5067640386 @default.
- W1986411547 hasAuthorship W1986411547A5069208817 @default.
- W1986411547 hasAuthorship W1986411547A5080657027 @default.
- W1986411547 hasAuthorship W1986411547A5089215094 @default.
- W1986411547 hasBestOaLocation W19864115471 @default.
- W1986411547 hasConcept C104317684 @default.
- W1986411547 hasConcept C114684123 @default.
- W1986411547 hasConcept C127716648 @default.
- W1986411547 hasConcept C142724271 @default.
- W1986411547 hasConcept C167672396 @default.
- W1986411547 hasConcept C181152851 @default.
- W1986411547 hasConcept C189165786 @default.
- W1986411547 hasConcept C203014093 @default.
- W1986411547 hasConcept C2776090121 @default.
- W1986411547 hasConcept C2776193487 @default.
- W1986411547 hasConcept C2778954852 @default.
- W1986411547 hasConcept C54355233 @default.
- W1986411547 hasConcept C71924100 @default.
- W1986411547 hasConcept C86803240 @default.
- W1986411547 hasConcept C8891405 @default.
- W1986411547 hasConcept C95444343 @default.
- W1986411547 hasConceptScore W1986411547C104317684 @default.
- W1986411547 hasConceptScore W1986411547C114684123 @default.
- W1986411547 hasConceptScore W1986411547C127716648 @default.
- W1986411547 hasConceptScore W1986411547C142724271 @default.
- W1986411547 hasConceptScore W1986411547C167672396 @default.
- W1986411547 hasConceptScore W1986411547C181152851 @default.
- W1986411547 hasConceptScore W1986411547C189165786 @default.
- W1986411547 hasConceptScore W1986411547C203014093 @default.
- W1986411547 hasConceptScore W1986411547C2776090121 @default.
- W1986411547 hasConceptScore W1986411547C2776193487 @default.
- W1986411547 hasConceptScore W1986411547C2778954852 @default.
- W1986411547 hasConceptScore W1986411547C54355233 @default.
- W1986411547 hasConceptScore W1986411547C71924100 @default.
- W1986411547 hasConceptScore W1986411547C86803240 @default.
- W1986411547 hasConceptScore W1986411547C8891405 @default.
- W1986411547 hasConceptScore W1986411547C95444343 @default.
- W1986411547 hasIssue "suppl 5" @default.
- W1986411547 hasLocation W19864115471 @default.
- W1986411547 hasLocation W19864115472 @default.
- W1986411547 hasLocation W19864115473 @default.
- W1986411547 hasLocation W19864115474 @default.
- W1986411547 hasOpenAccess W1986411547 @default.
- W1986411547 hasPrimaryLocation W19864115471 @default.
- W1986411547 hasRelatedWork W2015468821 @default.
- W1986411547 hasRelatedWork W2016112814 @default.
- W1986411547 hasRelatedWork W2031138144 @default.
- W1986411547 hasRelatedWork W2053350302 @default.
- W1986411547 hasRelatedWork W2093020311 @default.
- W1986411547 hasRelatedWork W2125939378 @default.
- W1986411547 hasRelatedWork W2129261229 @default.
- W1986411547 hasRelatedWork W2142660210 @default.
- W1986411547 hasRelatedWork W2150590994 @default.
- W1986411547 hasRelatedWork W72712021 @default.
- W1986411547 hasVolume "87" @default.
- W1986411547 isParatext "false" @default.
- W1986411547 isRetracted "false" @default.
- W1986411547 magId "1986411547" @default.
- W1986411547 workType "article" @default.