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- W1986447624 abstract "The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a Canadian initiative with the goal of performing standardized nasal allergen challenge (NAC) to study the effects of therapeutic agents for allergic rhinitis (AR), while allowing the identification of mechanisms and biomarkers of AR. Various NAC protocols have been described previously. The multiple cumulative allergen concentration (MCAC) NAC protocol was shown to produce more robust symptom scores than a cumulative allergen concentration (CAC) protocol. Here we examined NAC-induced eosinophilia for these two protocols. 17 atopic and 12 non-atopic participants were enrolled for this study. Atopic individuals presented with AR symptoms in ragweed season and a supportive skin test response. During screening incremental concentrations of ragweed allergen were administered until each participant reached the qualifying symptom cut-off. For the subsequent NAC one week later, ten atopics were challenged with one dose of allergen equivalent to the cumulative amount of allergen each received during screening (CAC). Seven atopics received the cumulative of all preceding allergen doses to the qualifying concentration (QC), followed by the QC 15 minutes later (MCAC). Non-atopics were challenged with a 1:2 ragweed concentration. Nasal lavage samples were collected at baseline, 1 hour (1H) and 6 hours (6H) post NAC to determine differential counts. The eosinophil fraction was significantly increased in atopics following NAC when compared to non-allergics at both 1H and 6H for the CAC-protocol but only at 6H for the MCAC-protocol. Even though the MCAC protocol establishes more robust symptom scores, the CAC protocol appears to produce more pronounced eosinophilia." @default.
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- W1986447624 date "2015-02-01" @default.
- W1986447624 modified "2023-09-23" @default.
- W1986447624 title "Nasal Allergen Challenge (NAC) Induced Eosinophilia - the Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC)" @default.
- W1986447624 doi "https://doi.org/10.1016/j.jaci.2014.12.1663" @default.
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