Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986451738> ?p ?o ?g. }
- W1986451738 endingPage "1113" @default.
- W1986451738 startingPage "1105" @default.
- W1986451738 abstract "Apolipoprotein J/clusterin (apoJ/clusterin), an intriguing protein with unknown function, is induced in myocarditis and numerous other inflammatory injuries. To test its ability to modify myosin-induced autoimmune myocarditis, we generated apoJ-deficient mice. ApoJ-deficient and wild-type mice exhibited similar initial onset of myocarditis, as evidenced by the induction of two early markers of the T cell–mediated immune response, MHC-II and TNF receptor p55. Furthermore, autoantibodies against the primary antigen cardiac myosin were induced to the same extent. Although the same proportion of challenged animals exhibited some degree of inflammatory infiltrate, inflammation was more severe in apoJ-deficient animals. Inflammatory lesions were more diffuse and extensive in apoJ-deficient mice, particularly in females. In marked contrast to wild-type animals, the development of a strong generalized secondary response against cardiac antigens in apoJ-deficient mice was predictive of severe myocarditis. Wild-type mice with a strong Ab response to secondary antigens appeared to be protected from severe inflammation. After resolution of inflammation, apoJ-deficient, but not wild-type, mice exhibited cardiac function impairment and severe myocardial scarring. These results suggest that apoJ limits progression of autoimmune myocarditis and protects the heart from postinflammatory tissue destruction." @default.
- W1986451738 created "2016-06-24" @default.
- W1986451738 creator A5014155025 @default.
- W1986451738 creator A5023640583 @default.
- W1986451738 creator A5029124172 @default.
- W1986451738 creator A5043691932 @default.
- W1986451738 creator A5052372262 @default.
- W1986451738 creator A5053399096 @default.
- W1986451738 creator A5061544783 @default.
- W1986451738 creator A5064856328 @default.
- W1986451738 creator A5069727180 @default.
- W1986451738 creator A5074214079 @default.
- W1986451738 creator A5081835053 @default.
- W1986451738 creator A5091646496 @default.
- W1986451738 date "2000-11-01" @default.
- W1986451738 modified "2023-10-17" @default.
- W1986451738 title "Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis" @default.
- W1986451738 cites W1569797408 @default.
- W1986451738 cites W1598858561 @default.
- W1986451738 cites W160393575 @default.
- W1986451738 cites W1607912577 @default.
- W1986451738 cites W1792678902 @default.
- W1986451738 cites W1875946043 @default.
- W1986451738 cites W1925698292 @default.
- W1986451738 cites W1926671788 @default.
- W1986451738 cites W1949149840 @default.
- W1986451738 cites W1956906199 @default.
- W1986451738 cites W1966282437 @default.
- W1986451738 cites W1967259696 @default.
- W1986451738 cites W1968802505 @default.
- W1986451738 cites W1968923954 @default.
- W1986451738 cites W1973182939 @default.
- W1986451738 cites W1974525741 @default.
- W1986451738 cites W1977331514 @default.
- W1986451738 cites W1980014228 @default.
- W1986451738 cites W1983391435 @default.
- W1986451738 cites W1996945731 @default.
- W1986451738 cites W1998960257 @default.
- W1986451738 cites W2000365663 @default.
- W1986451738 cites W2005551358 @default.
- W1986451738 cites W2013356418 @default.
- W1986451738 cites W2015543995 @default.
- W1986451738 cites W2018289835 @default.
- W1986451738 cites W2019903573 @default.
- W1986451738 cites W2019906171 @default.
- W1986451738 cites W2019951936 @default.
- W1986451738 cites W2026084826 @default.
- W1986451738 cites W2032130576 @default.
- W1986451738 cites W2034623333 @default.
- W1986451738 cites W2034733471 @default.
- W1986451738 cites W2044069347 @default.
- W1986451738 cites W2046570906 @default.
- W1986451738 cites W2050033307 @default.
- W1986451738 cites W2062766813 @default.
- W1986451738 cites W2064123556 @default.
- W1986451738 cites W2069684550 @default.
- W1986451738 cites W2075098575 @default.
- W1986451738 cites W2076632262 @default.
- W1986451738 cites W2077019499 @default.
- W1986451738 cites W2087593442 @default.
- W1986451738 cites W2087750804 @default.
- W1986451738 cites W2095394161 @default.
- W1986451738 cites W2100837269 @default.
- W1986451738 cites W2115888933 @default.
- W1986451738 cites W2128675390 @default.
- W1986451738 cites W2146909631 @default.
- W1986451738 cites W2149279617 @default.
- W1986451738 cites W2154094147 @default.
- W1986451738 cites W2161154771 @default.
- W1986451738 cites W2165033740 @default.
- W1986451738 cites W2170985289 @default.
- W1986451738 cites W2304106988 @default.
- W1986451738 cites W2398655886 @default.
- W1986451738 cites W2407616439 @default.
- W1986451738 cites W2413542342 @default.
- W1986451738 cites W2416539909 @default.
- W1986451738 cites W2464621808 @default.
- W1986451738 cites W283352782 @default.
- W1986451738 cites W31917203 @default.
- W1986451738 cites W1814241399 @default.
- W1986451738 doi "https://doi.org/10.1172/jci9037" @default.
- W1986451738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/301413" @default.
- W1986451738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11067863" @default.
- W1986451738 hasPublicationYear "2000" @default.
- W1986451738 type Work @default.
- W1986451738 sameAs 1986451738 @default.
- W1986451738 citedByCount "190" @default.
- W1986451738 countsByYear W19864517382012 @default.
- W1986451738 countsByYear W19864517382013 @default.
- W1986451738 countsByYear W19864517382014 @default.
- W1986451738 countsByYear W19864517382015 @default.
- W1986451738 countsByYear W19864517382016 @default.
- W1986451738 countsByYear W19864517382017 @default.
- W1986451738 countsByYear W19864517382018 @default.
- W1986451738 countsByYear W19864517382019 @default.
- W1986451738 countsByYear W19864517382020 @default.
- W1986451738 countsByYear W19864517382021 @default.
- W1986451738 countsByYear W19864517382022 @default.