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- W1986461448 abstract "The thyroid hormone binding protein transthyretin (TTR) forms a macromolecular complex with the retinol‐specific carrier retinol binding protein (RBP) in the blood of higher vertebrates. Piscine TTR is shown here to exhibit high binding affinity for L ‐thyroxine and negligible affinity for RBP. The 1.56 Å resolution X‐ray structure of sea bream TTR, compared with that of human TTR, reveals a high degree of conservation of the thyroid hormone binding sites. In contrast, some amino acid differences in discrete regions of sea bream TTR appear to be responsible for the lack of protein–protein recognition, providing evidence for the crucial role played by a limited number of residues in the interaction between RBP and TTR. Overall, this study makes it possible to draw conclusions on evolutionary relationships for RBPs and TTRs of phylogenetically distant vertebrates." @default.
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- W1986461448 date "2003-11-06" @default.
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- W1986461448 title "Distinctive binding and structural properties of piscine transthyretin" @default.
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- W1986461448 doi "https://doi.org/10.1016/s0014-5793(03)01248-1" @default.
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