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- W1986485557 abstract "A prospective, open-label, multicenter, Phase IV study of the efficacy and safety of intravenous (IV) ciprofloxacin (400 mg by 60-minute infusion every 12 hours) in the treatment of lower respiratory tract infections (LRTIs), urinary tract infections (UTIs), and skin/skin structure infections (SSSIs) in hospitalized patients was conducted in 1991. After a minimum of 3 days of IV therapy, patients could be switched to oral therapy with any antimicrobial. Of 360 patients who were valid for investigator assessment of clinical outcome at the end of IV therapy, a favorable outcome (cure and improvement in infection) was reported in 337 (94%) patients and failure was reported in 23 (6%) patients. Of 330 patients valid for investigation assessment of clinical outcome at the end of all therapy (IV treatment alone or IV treatment followed by an oral antimicrobial), a favorable outcome was noted in 311 (94%) patients, and failure occurred in 19 (6%) patients. Adverse events were noted in 72 (9%) of 782 patients and led to premature discontinuation of IV therapy in 23 (3%) patients. IV ciprofloxacin appears to be effective and safe in the management of mild-to-moderate LRTI and SSSI and mild, moderate, or severe UTI in hospitalized patients." @default.
- W1986485557 created "2016-06-24" @default.
- W1986485557 creator A5057870795 @default.
- W1986485557 date "1995-05-01" @default.
- W1986485557 modified "2023-09-23" @default.
- W1986485557 title "Multicenter, Phase IV evaluation of intravenous cirpfloxacin as initial therapy in patients with lower respiratory tract, urinary tract, and skin/skin structure infections" @default.
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- W1986485557 doi "https://doi.org/10.1016/0149-2918(95)80101-4" @default.
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