FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986549209> ?p ?o ?g. }

• W1986549209 endingPage "95" @default.
• W1986549209 startingPage "87" @default.
• W1986549209 abstract "Nitrogen-containing analogs of chrysene, 1,10-diazachrysene (1,10-DAC) and 4,10-DAC, were tested for mutagenicity in Salmonella typhimurium TA100 in the presence of rat liver S9 and human liver microsomes to investigate the effect of nitrogen-substitution. Although these DACs could not be converted to the bay-region diol epoxide because of their nitrogen atoms in the bay-region epoxide or diol moiety, DACs were mutagenic in the Ames test with rat liver S9. Both DACs also showed mutagenicity in the Ames test using pooled human liver microsomes, although chrysene itself was not mutagenic in the presence of pooled human liver microsomes. The mutagenicity of DACs (50nmol/plate) in Ames tests using human liver microsome preparations from 10 individuals was compared with cytochrome P450 (CYP) activity in each microsome preparation to investigate the CYP isoform involved in the activation of DACs to the genotoxic forms. The numbers of induced revertants obtained by 1,10-DAC varied 6.2-folds (109-680) and those by 4,10-DAC 4.8-folds (155-751) among the 10 individuals. The number of induced revertants obtained by 1,10-DAC significantly correlated with the CYP1A2-selective catalytic activity (r=0.84, P<0.01) in each microsome preparation. On the other hand, the number of induced revertants obtained by 4,10-DAC significantly correlated with the combined activity of CYP2A6 and 1A2 (CYP2A6+0.51xCYP1A2; r=0.75, P<0.01). However, in Ames tests using microsomes from insect cells expressing various human CYP isoforms, the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2, whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC. These results suggest that 1,10-DAC shows the mutagenicity through involvement of CYP1A2 in human liver, and 4,10-DAC does so through both CYP2A6 and 1A2. In conclusion, our results suggested that the difference in the nitrogen-substituted position in the chrysene molecule might affect the mutagenic activity through influencing the ratio of participation of the metabolic activation enzyme isoforms of CYP." @default.
• W1986549209 created "2016-06-24" @default.
• W1986549209 creator A5001776641 @default.
• W1986549209 creator A5003501947 @default.
• W1986549209 creator A5055461340 @default.
• W1986549209 creator A5065821856 @default.
• W1986549209 creator A5080247688 @default.
• W1986549209 date "2005-09-01" @default.
• W1986549209 modified "2023-09-30" @default.
• W1986549209 title "Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs" @default.
• W1986549209 cites W1543102669 @default.
• W1986549209 cites W1585787247 @default.
• W1986549209 cites W1964676026 @default.
• W1986549209 cites W1967050787 @default.
• W1986549209 cites W1970089074 @default.
• W1986549209 cites W1973195696 @default.
• W1986549209 cites W1976917904 @default.
• W1986549209 cites W1984734699 @default.
• W1986549209 cites W1993780682 @default.
• W1986549209 cites W1994271467 @default.
• W1986549209 cites W1998138883 @default.
• W1986549209 cites W2005156172 @default.
• W1986549209 cites W2006886368 @default.
• W1986549209 cites W2007972960 @default.
• W1986549209 cites W2008516711 @default.
• W1986549209 cites W2017605000 @default.
• W1986549209 cites W2031101878 @default.
• W1986549209 cites W2033458542 @default.
• W1986549209 cites W2044575308 @default.
• W1986549209 cites W2050595882 @default.
• W1986549209 cites W2061001060 @default.
• W1986549209 cites W2061267844 @default.
• W1986549209 cites W2067226452 @default.
• W1986549209 cites W2067402482 @default.
• W1986549209 cites W2071360084 @default.
• W1986549209 cites W2071583942 @default.
• W1986549209 cites W2074258278 @default.
• W1986549209 cites W2078007780 @default.
• W1986549209 cites W2088342692 @default.
• W1986549209 cites W2092959529 @default.
• W1986549209 cites W2103715266 @default.
• W1986549209 cites W2134325441 @default.
• W1986549209 cites W2142926482 @default.
• W1986549209 cites W2315114661 @default.
• W1986549209 cites W2319803135 @default.
• W1986549209 cites W2320382283 @default.
• W1986549209 cites W2330339879 @default.
• W1986549209 cites W4231793073 @default.
• W1986549209 doi "https://doi.org/10.1016/j.mrgentox.2005.06.006" @default.
• W1986549209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16087391" @default.
• W1986549209 hasPublicationYear "2005" @default.
• W1986549209 type Work @default.
• W1986549209 sameAs 1986549209 @default.
• W1986549209 citedByCount "6" @default.
• W1986549209 countsByYear W19865492092014 @default.
• W1986549209 countsByYear W19865492092019 @default.
• W1986549209 crossrefType "journal-article" @default.
• W1986549209 hasAuthorship W1986549209A5001776641 @default.
• W1986549209 hasAuthorship W1986549209A5003501947 @default.
• W1986549209 hasAuthorship W1986549209A5055461340 @default.
• W1986549209 hasAuthorship W1986549209A5065821856 @default.
• W1986549209 hasAuthorship W1986549209A5080247688 @default.
• W1986549209 hasConcept C114246631 @default.
• W1986549209 hasConcept C117632636 @default.
• W1986549209 hasConcept C178790620 @default.
• W1986549209 hasConcept C181199279 @default.
• W1986549209 hasConcept C185592680 @default.
• W1986549209 hasConcept C202751555 @default.
• W1986549209 hasConcept C2775959351 @default.
• W1986549209 hasConcept C2776524530 @default.
• W1986549209 hasConcept C2776639595 @default.
• W1986549209 hasConcept C2778951431 @default.
• W1986549209 hasConcept C2780768313 @default.
• W1986549209 hasConcept C2781065037 @default.
• W1986549209 hasConcept C523546767 @default.
• W1986549209 hasConcept C526171541 @default.
• W1986549209 hasConcept C54355233 @default.
• W1986549209 hasConcept C55493867 @default.
• W1986549209 hasConcept C71240020 @default.
• W1986549209 hasConcept C86803240 @default.
• W1986549209 hasConcept C87644729 @default.
• W1986549209 hasConceptScore W1986549209C114246631 @default.
• W1986549209 hasConceptScore W1986549209C117632636 @default.
• W1986549209 hasConceptScore W1986549209C178790620 @default.
• W1986549209 hasConceptScore W1986549209C181199279 @default.
• W1986549209 hasConceptScore W1986549209C185592680 @default.
• W1986549209 hasConceptScore W1986549209C202751555 @default.
• W1986549209 hasConceptScore W1986549209C2775959351 @default.
• W1986549209 hasConceptScore W1986549209C2776524530 @default.
• W1986549209 hasConceptScore W1986549209C2776639595 @default.
• W1986549209 hasConceptScore W1986549209C2778951431 @default.
• W1986549209 hasConceptScore W1986549209C2780768313 @default.
• W1986549209 hasConceptScore W1986549209C2781065037 @default.
• W1986549209 hasConceptScore W1986549209C523546767 @default.
• W1986549209 hasConceptScore W1986549209C526171541 @default.
• W1986549209 hasConceptScore W1986549209C54355233 @default.
• W1986549209 hasConceptScore W1986549209C55493867 @default.
• W1986549209 hasConceptScore W1986549209C71240020 @default.

• next