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- W1986562974 abstract "Two defensin genes A and B were previously demonstrated to be up-regulated by blood feeding in the soft tick, Ornithodoros moubata [Nakajima et al. (2001) Two isoforms of a member of the arthropod defensin family from the soft tick, Ornithodoros moubata (Acari: Argasidae). Insect Biochem Mol Biol 31: 747-751]. In this study, two defensin isoforms C and D similar to defensins A and B were newly cloned. A total of four defensins have been identified in O. moubata. All four Ornithodoros defensins are coded as prepro-defensins. Ornithodoros defensin genes consist of four exons and three introns, an organization reported in mussel defensins but not insect defensins. Ornithodoros defensin C and D genes are predominantly expressed in the midgut and up-regulated in response to blood feeding. The mature peptide of the previously cloned Ornithodoros defensin A was purified from the midgut lumen, indicating defensin is secreted into the midgut. These findings confirm the involvement of Ornithodoros defensin in midgut immunity." @default.
- W1986562974 created "2016-06-24" @default.
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- W1986562974 date "2002-12-01" @default.
- W1986562974 modified "2023-10-12" @default.
- W1986562974 title "Antibacterial peptide defensin is involved in midgut immunity of the soft tick, Ornithodoros moubata" @default.
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- W1986562974 doi "https://doi.org/10.1046/j.1365-2583.2002.00372.x" @default.
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