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• W1986578270 endingPage "717" @default.
• W1986578270 startingPage "629" @default.
• W1986578270 abstract "Background Acute respiratory tract infections (ARTIs) are a major cause of childhood morbidity and mortality. Immunostimulants (IS) may reduce the incidence of ARTIs. Objectives To determine the efficacy and safety of IS in preventing ARTIs in children. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) 2011, issue 1, which contains the Acute Respiratory Infections Group's Specialised Register, MEDLINE (1966 to February week 4, 2011), EMBASE (1990 to February 2011), Google Scholar (2009 to February 2011), Scopus (2009 to February 2011), PASCAL (1990 to February 2010), SciSearch (1990 to February 2010) and IPA (1990 to February 2010). Selection criteria We included all comparative randomized controlled trials (RCTs) which enrolled participants less than 18 years of age. The intervention was IS medication, administered by any method, compared to placebo to prevent ARTIs. Data collection and analysis We analyzed the outcome on ARTIs both as the mean number of ARTIs by group and as a percent change in the rate of ARTIs. We undertook meta-analyses using a random-effects model and presented results as mean differences (MD) with 95% confidence intervals (CI). Two review authors independently assessed the search results and risk of bias, and extracted data. A funnel plot suggested there may be publication bias in the identified trials. Main results Thirty-five placebo-controlled trials (4060 participants) provided data in a form suitable for inclusion in the meta-analyses. When compared with placebo, the use of IS was shown to reduce ARTIs measured as the total numbers of ARTIs (MD -1.24; 95% CI -1.54 to -0.94) and the difference in ARTI rates (MD -38.84%; 95% CI -46.37% to -31.31%). Trial quality was generally poor and a high level of statistical heterogeneity was evident. The subgroup analysis of bacterial IS, D53 and OM-85 studies produced similar results, with lower heterogeneity. No difference in adverse events was evident between the placebo and IS groups. Authors' conclusions This review shows that IS reduce the incidence of ARTIs by 40% on average in susceptible children. Studies in healthy children are not available. Although the safety profile in the studies was good, some IS may be unsafe. ARTI-susceptible children may benefit from IS treatment. Further high-quality trials are needed and we encourage national health authorities to conduct large, multicentre, double-blind, placebo-controlled RCTs on the role of IS in preventing ARTIs in children. Plain Language Summary Immunostimulants to prevent acute respiratory tract infections in children Acute respiratory tract infections (ARTIs) are responsible for 19% of all deaths in children younger than five years of age, mainly in low-income countries in Africa, Asia and Latin America. In high-income countries ARTIs are among the most frequent illnesses, leading to 20% of medical consultations, 30% of days lost from work and 75% of antibiotic prescriptions. In the USA the total cost of non-influenza-related viral ARTIs is around $40 billion annually, while the corresponding cost for influenza is US $87.1 billion. The main signs and symptoms of ARTIs include sneezing, runny nose, sore throat, cough and malaise. Children living in rural communities, not attending daycare centres, suffer about seven ARTI episodes in the first year of life; eight ARTIs per year from the ages of one to four; six per year aged five to nine; and five per year aged 10 to 19. Children exposed to risks factors, such as attendance at daycare centres, overcrowding, contact with older siblings, smoking at home and lack of breast feeding, may suffer more ARTIs. Several treatments have been used to reduce the incidence of ARTIs (vitamin A, vitamin C, zinc, antibiotics). Among them are immunostimulants (herbal extracts, bacterial extracts, synthetic compounds), which aim to increase the immune defences of the respiratory tract. We searched for clinical trials of immunostimulants to prevent ARTIs in children compared to placebo. Our review includes 35 studies with 4060 participants. However, the quality of many of the studies was poor and the results were very diverse. By combining results, immunostimulants reduced 1.24 ARTIs in a six-month period, equivalent to a 39% reduction in ARTIs compared to the placebo group. Only 20 studies provided adequate data on adverse events: the most frequent were rash, nausea, vomiting, abdominal pain and diarrhea. The main limitations of this review were the poor methodological quality and diverse trial results. We conclude that ARTI-susceptible children may benefit from immunostimulants, but more high-quality studies are needed. We suggest that national health authorities conduct high-quality randomized controlled trials to assess the true effects of immunostimulant preparations." @default.
• W1986578270 created "2016-06-24" @default.
• W1986578270 creator A5006553059 @default.
• W1986578270 creator A5013492956 @default.
• W1986578270 creator A5020808490 @default.
• W1986578270 creator A5057959686 @default.
• W1986578270 date "2012-03-01" @default.
• W1986578270 modified "2023-10-14" @default.
• W1986578270 title "Cochrane Review: Immunostimulants for preventing respiratory tract infection in children" @default.
• W1986578270 cites W1484565560 @default.
• W1986578270 cites W1525912444 @default.
• W1986578270 cites W1560114018 @default.
• W1986578270 cites W1565193648 @default.
• W1986578270 cites W1966497743 @default.
• W1986578270 cites W1967300438 @default.
• W1986578270 cites W1969734467 @default.
• W1986578270 cites W1969934047 @default.
• W1986578270 cites W1971972737 @default.
• W1986578270 cites W1972776583 @default.
• W1986578270 cites W1975643966 @default.
• W1986578270 cites W1979374514 @default.
• W1986578270 cites W1984151185 @default.
• W1986578270 cites W1985607069 @default.
• W1986578270 cites W1986083785 @default.
• W1986578270 cites W1986231627 @default.
• W1986578270 cites W1989324226 @default.
• W1986578270 cites W1989814610 @default.
• W1986578270 cites W1991957164 @default.
• W1986578270 cites W1992019058 @default.
• W1986578270 cites W1994119684 @default.
• W1986578270 cites W1998747507 @default.
• W1986578270 cites W2001187841 @default.
• W1986578270 cites W2001819986 @default.
• W1986578270 cites W2002300697 @default.
• W1986578270 cites W2004233179 @default.
• W1986578270 cites W2005041676 @default.
• W1986578270 cites W2007491524 @default.
• W1986578270 cites W2008870732 @default.
• W1986578270 cites W2011138763 @default.
• W1986578270 cites W2011515987 @default.
• W1986578270 cites W2013829912 @default.
• W1986578270 cites W2016736819 @default.
• W1986578270 cites W2018976239 @default.
• W1986578270 cites W2029012995 @default.
• W1986578270 cites W2038758282 @default.
• W1986578270 cites W2047454295 @default.
• W1986578270 cites W2050047704 @default.
• W1986578270 cites W2050415939 @default.
• W1986578270 cites W2050436579 @default.
• W1986578270 cites W2053832675 @default.
• W1986578270 cites W2053935131 @default.
• W1986578270 cites W2055171241 @default.
• W1986578270 cites W2055395401 @default.
• W1986578270 cites W2056763100 @default.
• W1986578270 cites W2059168447 @default.
• W1986578270 cites W2061297849 @default.
• W1986578270 cites W2064020378 @default.
• W1986578270 cites W2068240651 @default.
• W1986578270 cites W2069462575 @default.
• W1986578270 cites W2072530712 @default.
• W1986578270 cites W2072997836 @default.
• W1986578270 cites W2075787303 @default.
• W1986578270 cites W2077913253 @default.
• W1986578270 cites W2079735320 @default.
• W1986578270 cites W2085116183 @default.
• W1986578270 cites W2085763011 @default.
• W1986578270 cites W2090746203 @default.
• W1986578270 cites W2093175349 @default.
• W1986578270 cites W2093963744 @default.
• W1986578270 cites W2094161521 @default.
• W1986578270 cites W2094279863 @default.
• W1986578270 cites W2094563797 @default.
• W1986578270 cites W2095307926 @default.
• W1986578270 cites W2097014240 @default.
• W1986578270 cites W2099319343 @default.
• W1986578270 cites W2107533173 @default.
• W1986578270 cites W2111035947 @default.
• W1986578270 cites W2114626700 @default.
• W1986578270 cites W2115668399 @default.
• W1986578270 cites W2117483881 @default.
• W1986578270 cites W2125435699 @default.
• W1986578270 cites W2129276127 @default.
• W1986578270 cites W2137313784 @default.
• W1986578270 cites W2137407508 @default.
• W1986578270 cites W2138597393 @default.
• W1986578270 cites W2144081943 @default.
• W1986578270 cites W2147230281 @default.
• W1986578270 cites W2151767234 @default.
• W1986578270 cites W2152240392 @default.
• W1986578270 cites W2154782136 @default.
• W1986578270 cites W2157823046 @default.
• W1986578270 cites W2160930945 @default.
• W1986578270 cites W2163480358 @default.
• W1986578270 cites W2167282384 @default.
• W1986578270 cites W2184741435 @default.
• W1986578270 cites W2260494648 @default.
• W1986578270 cites W2273207595 @default.
• W1986578270 cites W2317705821 @default.

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