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• W1986579608 abstract "Spontaneous mutations are thought to occur primarily in growing cells. However, spontaneous mutations also arise in nutritionally deprived cells, and in some cases this process appears to be adaptive. Here it is reported that when a Lac- strain of Escherichia coli is under selection for lactose use, the spectrum of Lac+ mutations that arises is different, and simpler, than that arising without selection. Mutations appearing during selection were mainly one-base deletions in runs of iterated bases. Similar mutations occurring in repetitive DNA elements are associated with a variety of human hereditary diseases and are increased in cells that cannot correct heteroduplex DNA." @default.
• W1986579608 created "2016-06-24" @default.
• W1986579608 creator A5020453712 @default.
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• W1986579608 date "1994-07-15" @default.
• W1986579608 modified "2023-10-12" @default.
• W1986579608 title "Adaptive Reversion of a Frameshift Mutation in <i>Escherichia coli</i> by Simple Base Deletions in Homopolymeric Runs" @default.
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• W1986579608 doi "https://doi.org/10.1126/science.8023164" @default.
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