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• W1986583100 startingPage "719" @default.
• W1986583100 abstract "CONTRACTING GRANULATION TISSUES CONTAIN FIBROBLASTS THAT DEVELOP CHARACTERISTICS TYPICAL OF SMOOTH MUSCLE: (a) They contain an extensive cytoplasmic fibrillar system. (b) They show immunofluorescent labeling of their cytoplasm with human anti-smooth muscle serum. (c) The nuclei show complicated folds and indentations, indicative of cellular contraction. (d) There are cell-to-cell and cell-to-stroma attachments. (e) It is possible to extract similar quantities of actomyosin (having the same adenosine triphosphatase activity) from granulation tissue and from pregnant rat uterus. (f) Strips of granulation tissue, when tested pharmacologically in vitro, behave similarly to smooth muscle. All these data support the view that, under certain conditions, fibroblasts can differentiate into a cell type structurally and functionally similar to smooth muscle and that this cell, the myo-fibroblast, plays an important role in connective tissue contraction." @default.
• W1986583100 created "2016-06-24" @default.
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• W1986583100 date "1972-04-01" @default.
• W1986583100 modified "2023-10-15" @default.
• W1986583100 title "GRANULATION TISSUE AS A CONTRACTILE ORGAN" @default.
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• W1986583100 doi "https://doi.org/10.1084/jem.135.4.719" @default.
• W1986583100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2139162" @default.
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