Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986585280> ?p ?o ?g. }
- W1986585280 endingPage "422" @default.
- W1986585280 startingPage "408" @default.
- W1986585280 abstract "The multiligand receptor RAGE (receptor for advanced glycation end-products) is emerging as a central mediator in the immune/inflammatory response. Epidemiological evidence accruing in the human suggests upregulation of RAGE's ligands (AGEs, S100/calgranulins, high mobility group box-1 (HMGB1), and amyloid beta-peptide and beta-sheet fibrils) and the receptor itself at sites of inflammation and in chronic diseases such as diabetes and neurodegeneration. The consequences of ligand-RAGE interaction include upregulation of molecules implicated in inflammatory responses and tissue damage, such as cytokines, adhesion molecules, and matrix metalloproteinases. In this review, we discuss the localization of RAGE and its ligand families and the biological impact of this axis in multiple cell types implicated in chronic diseases. Lastly, we consider findings from animal model studies suggesting that although tissue-damaging effects ensue from recruitment of the ligand-RAGE interaction, in distinct settings, adaptive and repair/regeneration outcomes appear to override detrimental effects of RAGE. As RAGE blockade moves further into clinical development, clarifying the biology of RAGE garners ever-increasing importance." @default.
- W1986585280 created "2016-06-24" @default.
- W1986585280 creator A5007603996 @default.
- W1986585280 creator A5012675757 @default.
- W1986585280 creator A5038128976 @default.
- W1986585280 creator A5051573119 @default.
- W1986585280 date "2009-01-01" @default.
- W1986585280 modified "2023-09-23" @default.
- W1986585280 title "Tempering the wrath of RAGE: An emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation" @default.
- W1986585280 cites W1513611092 @default.
- W1986585280 cites W1549583774 @default.
- W1986585280 cites W1572011530 @default.
- W1986585280 cites W1594856996 @default.
- W1986585280 cites W1645795322 @default.
- W1986585280 cites W1831226188 @default.
- W1986585280 cites W1971177781 @default.
- W1986585280 cites W1972409318 @default.
- W1986585280 cites W1973346925 @default.
- W1986585280 cites W1978475948 @default.
- W1986585280 cites W1987796811 @default.
- W1986585280 cites W1990205058 @default.
- W1986585280 cites W1991338634 @default.
- W1986585280 cites W1999684267 @default.
- W1986585280 cites W2000281764 @default.
- W1986585280 cites W2003813921 @default.
- W1986585280 cites W2004266769 @default.
- W1986585280 cites W2004437604 @default.
- W1986585280 cites W2005640704 @default.
- W1986585280 cites W2006779270 @default.
- W1986585280 cites W2007281508 @default.
- W1986585280 cites W2008721781 @default.
- W1986585280 cites W2010140068 @default.
- W1986585280 cites W2013646064 @default.
- W1986585280 cites W2016370501 @default.
- W1986585280 cites W2017234408 @default.
- W1986585280 cites W2018629826 @default.
- W1986585280 cites W2020203901 @default.
- W1986585280 cites W2022660459 @default.
- W1986585280 cites W2026885016 @default.
- W1986585280 cites W2029789771 @default.
- W1986585280 cites W2034502915 @default.
- W1986585280 cites W2043296623 @default.
- W1986585280 cites W2047964022 @default.
- W1986585280 cites W2048031384 @default.
- W1986585280 cites W2049167261 @default.
- W1986585280 cites W2050093406 @default.
- W1986585280 cites W2056121897 @default.
- W1986585280 cites W2057616008 @default.
- W1986585280 cites W2058597871 @default.
- W1986585280 cites W2059217150 @default.
- W1986585280 cites W2059693555 @default.
- W1986585280 cites W2062389480 @default.
- W1986585280 cites W2071675524 @default.
- W1986585280 cites W2073714833 @default.
- W1986585280 cites W2074465835 @default.
- W1986585280 cites W2079407096 @default.
- W1986585280 cites W2083419397 @default.
- W1986585280 cites W2096678432 @default.
- W1986585280 cites W2098767525 @default.
- W1986585280 cites W2102161478 @default.
- W1986585280 cites W2106697731 @default.
- W1986585280 cites W2108690001 @default.
- W1986585280 cites W2110458832 @default.
- W1986585280 cites W2111463022 @default.
- W1986585280 cites W2114688115 @default.
- W1986585280 cites W2115293825 @default.
- W1986585280 cites W2116576448 @default.
- W1986585280 cites W2117690477 @default.
- W1986585280 cites W2117783767 @default.
- W1986585280 cites W2118273829 @default.
- W1986585280 cites W2119014922 @default.
- W1986585280 cites W2119150369 @default.
- W1986585280 cites W2120212913 @default.
- W1986585280 cites W2120842870 @default.
- W1986585280 cites W2121453706 @default.
- W1986585280 cites W2121527030 @default.
- W1986585280 cites W2123027695 @default.
- W1986585280 cites W2125175295 @default.
- W1986585280 cites W2129227455 @default.
- W1986585280 cites W2129902595 @default.
- W1986585280 cites W2130072278 @default.
- W1986585280 cites W2130775443 @default.
- W1986585280 cites W2131096470 @default.
- W1986585280 cites W2135934951 @default.
- W1986585280 cites W2136294641 @default.
- W1986585280 cites W2137769185 @default.
- W1986585280 cites W2138928713 @default.
- W1986585280 cites W2140324784 @default.
- W1986585280 cites W2143998429 @default.
- W1986585280 cites W2146666237 @default.
- W1986585280 cites W2148329662 @default.
- W1986585280 cites W2148715056 @default.
- W1986585280 cites W2149342137 @default.
- W1986585280 cites W2150107415 @default.
- W1986585280 cites W2150611166 @default.
- W1986585280 cites W2155742637 @default.
- W1986585280 cites W2157935084 @default.
- W1986585280 cites W2162666481 @default.