Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986587854> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1986587854 endingPage "715" @default.
- W1986587854 startingPage "708" @default.
- W1986587854 abstract "A series of TCD50 experiments using a spontaneously arising, syngeneically transplated, murine squamous carcinoma is reported. Tumours implanted intradermally and irradiated while they remained superficial had a small but nonetheless cure-limiting hypoxic fraction of cells (TCD50 3,324-4,257 rad). The hypoxic fraction increased dramatically when these tumours invaded the subcutaneous tissues, or when tumours were implanted subcutaneously (TCD50 greater than 5,544 rad). Pre-treatment of mice with the electron-affinic drug Ro-07-0582 at a dose of 1 mg/g i.p. 20-30 minutes before irradiation effectively eliminated the hypoxic element from superficaial tumours (TCD50 1.862 rad). The same drug at a dose of 0-25 mg/g reduced the TCD50 for superficial tumours by a factor of 1-87 (3,986-2,134 rad), while another electron affinic drug, metronidazole, given at a dose of 0-25 mg/g reduced the TCD50 by a factor of 1-28 (4,257-3,337 rad). Treatment of mice with the drug ICRF 159, 30 mug/g daily from the time of tumour cell injection until the day of irradiation, reduced the TCD50 in unclamped tumours by less than 1-19. However, a commensurate reduction of TCD50 in clamped tumours suggested that improved tumour vascularization could not explain fully the drug's radiosensitizing action. The unique single radiation dose curability of most human skin cancers is discussed in the light of the experimental results, and the possible clinical implication of an increase in hypoxic fraction with tumour invasion is raised." @default.
- W1986587854 created "2016-06-24" @default.
- W1986587854 creator A5058530373 @default.
- W1986587854 date "1976-08-01" @default.
- W1986587854 modified "2023-09-26" @default.
- W1986587854 title "Modification of the radiocurability of a syngeneic murine squamous carcinoma by its site of growth, by electron-affinic drugs, and by ICRF 159" @default.
- W1986587854 cites W1966631785 @default.
- W1986587854 cites W1982612005 @default.
- W1986587854 cites W2007342738 @default.
- W1986587854 cites W2031307716 @default.
- W1986587854 cites W2034870830 @default.
- W1986587854 cites W2046632822 @default.
- W1986587854 cites W2047943990 @default.
- W1986587854 cites W2055844343 @default.
- W1986587854 cites W2082408122 @default.
- W1986587854 cites W2086246819 @default.
- W1986587854 cites W2111685034 @default.
- W1986587854 cites W2113773304 @default.
- W1986587854 cites W2300809561 @default.
- W1986587854 doi "https://doi.org/10.1259/0007-1285-49-584-708" @default.
- W1986587854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/953390" @default.
- W1986587854 hasPublicationYear "1976" @default.
- W1986587854 type Work @default.
- W1986587854 sameAs 1986587854 @default.
- W1986587854 citedByCount "25" @default.
- W1986587854 crossrefType "journal-article" @default.
- W1986587854 hasAuthorship W1986587854A5058530373 @default.
- W1986587854 hasConcept C111337013 @default.
- W1986587854 hasConcept C121332964 @default.
- W1986587854 hasConcept C142724271 @default.
- W1986587854 hasConcept C185544564 @default.
- W1986587854 hasConcept C2780035454 @default.
- W1986587854 hasConcept C2989005 @default.
- W1986587854 hasConcept C502942594 @default.
- W1986587854 hasConcept C71924100 @default.
- W1986587854 hasConcept C98274493 @default.
- W1986587854 hasConceptScore W1986587854C111337013 @default.
- W1986587854 hasConceptScore W1986587854C121332964 @default.
- W1986587854 hasConceptScore W1986587854C142724271 @default.
- W1986587854 hasConceptScore W1986587854C185544564 @default.
- W1986587854 hasConceptScore W1986587854C2780035454 @default.
- W1986587854 hasConceptScore W1986587854C2989005 @default.
- W1986587854 hasConceptScore W1986587854C502942594 @default.
- W1986587854 hasConceptScore W1986587854C71924100 @default.
- W1986587854 hasConceptScore W1986587854C98274493 @default.
- W1986587854 hasIssue "584" @default.
- W1986587854 hasLocation W19865878541 @default.
- W1986587854 hasLocation W19865878542 @default.
- W1986587854 hasOpenAccess W1986587854 @default.
- W1986587854 hasPrimaryLocation W19865878541 @default.
- W1986587854 hasRelatedWork W108213934 @default.
- W1986587854 hasRelatedWork W2058270877 @default.
- W1986587854 hasRelatedWork W2077990344 @default.
- W1986587854 hasRelatedWork W2081685347 @default.
- W1986587854 hasRelatedWork W2144554917 @default.
- W1986587854 hasRelatedWork W2272899425 @default.
- W1986587854 hasRelatedWork W2274929222 @default.
- W1986587854 hasRelatedWork W2351641484 @default.
- W1986587854 hasRelatedWork W2426261983 @default.
- W1986587854 hasRelatedWork W2473431470 @default.
- W1986587854 hasVolume "49" @default.
- W1986587854 isParatext "false" @default.
- W1986587854 isRetracted "false" @default.
- W1986587854 magId "1986587854" @default.
- W1986587854 workType "article" @default.