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- W1986615265 abstract "Rapid increases in Ca2+ concentration, produced by photolysis of caged Ca2+, triggered exocytosis in squid nerve terminals. This exocytosis was transient in nature, decaying with a time constant of approximately 30 ms. The decay could not be explained by a decline in presynaptic Ca2+ concentration, depletion of synaptic vesicles, or desensitization of postsynaptic receptors. Experiments in which Ca2+ was increased either in a series of steps or continuously at different rates suggested that the decay is caused by adaptation of the exocytotic Ca2+ receptor to higher levels of Ca2+. This adjustable sensitivity to Ca2+ represents a novel property of the triggering mechanism that can be used to evaluate molecular models of exocytosis. Adaptation can limit the amount of transmitter released by a nerve terminal and permit the speed of a presynaptic Ca2+ rise to serve as a critical determinant of synaptic efficacy." @default.
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- W1986615265 date "1996-09-01" @default.
- W1986615265 modified "2023-10-07" @default.
- W1986615265 title "Adaptation of Ca2+-Triggered Exocytosis in Presynaptic Terminals" @default.
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- W1986615265 doi "https://doi.org/10.1016/s0896-6273(00)80182-8" @default.
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