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• W1986616424 abstract "The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic (trp) genes in response to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria. When activated by binding tryptophan, TRAP binds to the mRNAs of several genes involved in tryptophan metabolism, and down-regulates transcription or translation of these genes. Anti-TRAP (AT) is an antagonist of TRAP that binds to tryptophan-activated TRAP and prevents it from binding to its RNA targets, and thereby up-regulates trp gene expression. The crystal structure shows that AT is a cone-shaped trimer (AT3) with the N-terminal residues of the three subunits assembled at the apex of the cone and that these trimers can further assemble into a dodecameric (AT12) structure. Using alanine-scanning mutagenesis we found four residues, all located on the “top” region of AT3, that are essential for binding to TRAP. Fluorescent labeling experiments further suggest that the top region of AT is in close juxtaposition to TRAP in the AT-TRAP complex. In vivo studies confirmed the importance of these residues on the top of AT in regulating TRAP mediated gene regulation." @default.
• W1986616424 created "2016-06-24" @default.
• W1986616424 creator A5013174279 @default.
• W1986616424 creator A5014859221 @default.
• W1986616424 date "2008-04-01" @default.
• W1986616424 modified "2023-10-09" @default.
• W1986616424 title "Alanine Scanning Mutagenesis of Anti-TRAP (AT) Reveals Residues Involved in Binding to TRAP" @default.
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• W1986616424 doi "https://doi.org/10.1016/j.jmb.2008.02.015" @default.
• W1986616424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2330097" @default.
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