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- W1986619858 startingPage "4568" @default.
- W1986619858 abstract "Nucleotide‐binding oligomerization domain receptors ( NOD ‐like receptors, NLR s) are intracellular proteins that are chiefly known for their critical functions in inflammatory responses and host defense against microbial pathogens. Several NLR s have been demonstrated to assemble inflammasomes or to engage transcriptional signaling cascades that result in the production of pro‐inflammatory cytokines and bactericidal factors. In recent years, NLR s have also emerged as key regulators of early mammalian embryogenesis and reproduction. A subset of phylogenetically related NLR s represents a new class of maternal effect genes that are highly expressed in maturing oocytes and pre‐implantation embryos. Mutations in several of these NLR s have been linked to hereditary reproductive defects and imprinting diseases. In this review, we discuss the expression profiles, the emerging functions and molecular mode of action of these NLR s with newly recognized roles at the interfaces of the immune and reproductive systems. In addition, we provide an overview of coding mutations in NLR s that have been associated with human reproductive diseases, and outline crucial outstanding questions in this emerging research field." @default.
- W1986619858 created "2016-06-24" @default.
- W1986619858 creator A5014558436 @default.
- W1986619858 creator A5016211934 @default.
- W1986619858 creator A5048127391 @default.
- W1986619858 creator A5075609815 @default.
- W1986619858 date "2014-09-30" @default.
- W1986619858 modified "2023-10-04" @default.
- W1986619858 title "NOD-like receptors interfacing the immune and reproductive systems" @default.
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