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• W1986635542 abstract "We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majority of the mutations being found in ADC (adenocarcinoma, 27.0%). Mutational screening detected three different COX-2 mutations and five different P53 mutations, published for the first time. With RT-PCR we observed that the expression of the tested genes, hTERT and COX-2, was highly significant for ADC ( p < 0.01) and SCC ( p < 0.05). Statistical analysis of the combined results revealed significant correlation between expression of COX-2 and hTERT ( p < 0.001), hTERT expression and staging ( p < 0.05) and survival ( p < 0.01). A positive correlation between COX-2 expression and K-RAS mutation ( p <0.05) was also observed. This study provides insight into associations between the analysed biomarkers and the clinical-pathological data of the patients." @default.
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• W1986635542 date "2008-01-01" @default.
• W1986635542 modified "2023-09-26" @default.
• W1986635542 title "K-RAS and P53 Mutations in Association with COX-2 and Htert Expression and Clinico-Pathological Status of Nsclc Patients" @default.
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• W1986635542 doi "https://doi.org/10.1155/2008/232743" @default.
• W1986635542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3827803" @default.
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