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- W198664595 abstract "SUMMARY During a 12‐month study, 42 adult patients with febrile neutropenia (granulocytes <1 × 10 9 /l) were treated with once‐daily gentamicin (5 mg/kg). Serum gentamicin trough levels were measured 24 hours after the first dose, then twice weekly if <1 mg/l. Gentamicin was halved if the trough level was 1‐2 mg/l and usually stopped if >2 mg/l. One hundred and sixty samples were assayed: 122 (76%) <1 mg/l, 27 (17%) I‐2 mg/l and 11 (7%) >2 mg/l. All 1‐2 mg/l samples and three of the >2 mg/l samples (taken at the wrong time) reverted to <1 mg/l with dosage adjustment. The protocol proved simple and effective with a low incidence of gentamicin‐associated nephrotoxicity (7%) and no sepsis‐related deaths." @default.
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- W198664595 date "1997-06-01" @default.
- W198664595 modified "2023-09-26" @default.
- W198664595 title "AUDIT OF ONCE‐DAILY DOSING GENTAMICIN THERAPY IN NEUTROPENIC FEVER" @default.
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- W198664595 doi "https://doi.org/10.1111/j.1742-1241.1997.tb11439.x" @default.
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