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- W1986646720 abstract "The treatment of tumor cells in culture with chloroquine after irradiation significantly reduces their survival, but no enhancement is seen when the cells are treated with the drug before irradiation. This suggests that the potentiation of the radiation response by chloroquine results from the impairment of the post-irradiation recovery processes. Incorporation studies with melanotic melanoma cells in culture derived from human malignant melanoma demonstrate significantly higher uptake of the compound than in amelanotic melanoma, HeLa, or nonpigmented human diploid cells in culture. The significance of these findings is discussed in relation to the potential use of the drug as a radiosensitizer in selected human tumors." @default.
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- W1986646720 date "1973-09-01" @default.
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- W1986646720 title "Enhancement of the radiation response of cultured tumor cells by chloroquine" @default.
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- W1986646720 doi "https://doi.org/10.1002/1097-0142(197309)32:3<536::aid-cncr2820320304>3.0.co;2-e" @default.
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