Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986648376> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1986648376 endingPage "151" @default.
- W1986648376 startingPage "145" @default.
- W1986648376 abstract "Objective: Studies on the regulation of the fibrinolytic system of smooth muscle cells (SMC) are of importance for our understanding of the formation and stabilization of intravascular thrombi and the migration and proliferation of SMC during arterial injury and atheromatous plaque development. Results: We report here the stimulation of plasminogen activator inhibitor type-one (PAI-1) synthesis in cultured human mammary artery smooth muscle cells (HMASMC) by the macrophage inflammatory cytokines, interleukin 1α (IL-1α) and tumour necrosis factor-α (TNF-α). SMC responded to IL-1α and TNF-α treatment with a time- and dose-dependent increase in PAI-1 protein of up to 1.9- and 4.2-fold, respectively, as determined by ELISA. Maximum cytokine effects were achieved at 14 pM IL-1α and 10 nM TNF-α. Analysis of mRNA showed that 3.4 kb and 2.4 kb PAI-1 mRNA transcripts increased maximally by over 5- and 3-fold, respectively, after TNF-α treatment and by over 3- and 2-fold, respectively, after IL-1α treatment, compared to respective, untreated controls. IL-1α and TNF-α did not affect urokinase-type plasminogen activator (u-PA) synthesis while IL-1α decreased tissue-type plasminogen activator (t-PA) in conditioned medium. Conclusion: These results suggest that the fibrinolytic potential of SMC can be regulated by IL-1α and TNF-α which may be released by activated monocytes/macrophages, endothelial cells or SMC themselves during the development of atherosclerosis, vasculitis or vascular injury. Increased PAI-1 would suggest an antifibrinolytic tendency in the SMC microenvironment in response to IL-1α and/or TNF-α exposure." @default.
- W1986648376 created "2016-06-24" @default.
- W1986648376 creator A5016842679 @default.
- W1986648376 creator A5026903949 @default.
- W1986648376 creator A5056242060 @default.
- W1986648376 creator A5073815096 @default.
- W1986648376 date "1995-05-01" @default.
- W1986648376 modified "2023-10-18" @default.
- W1986648376 title "Regulation of plasminogen activator inhibitor type 1 in cultured smooth muscle cells by interleukin 1α and tumour necrosis factor-α" @default.
- W1986648376 cites W1595391532 @default.
- W1986648376 cites W1597535871 @default.
- W1986648376 cites W1602113709 @default.
- W1986648376 cites W1945199177 @default.
- W1986648376 cites W1965876706 @default.
- W1986648376 cites W1973696220 @default.
- W1986648376 cites W1989565327 @default.
- W1986648376 cites W1993981607 @default.
- W1986648376 cites W2017796558 @default.
- W1986648376 cites W2017819390 @default.
- W1986648376 cites W2033741891 @default.
- W1986648376 cites W2047797817 @default.
- W1986648376 cites W2060333964 @default.
- W1986648376 cites W2066775818 @default.
- W1986648376 cites W2069279553 @default.
- W1986648376 cites W2077861410 @default.
- W1986648376 cites W2080858331 @default.
- W1986648376 cites W2096312838 @default.
- W1986648376 cites W2100994529 @default.
- W1986648376 cites W2137306171 @default.
- W1986648376 cites W2147274452 @default.
- W1986648376 cites W2398562114 @default.
- W1986648376 cites W2403169180 @default.
- W1986648376 cites W2413062223 @default.
- W1986648376 cites W2470108098 @default.
- W1986648376 cites W4242083419 @default.
- W1986648376 doi "https://doi.org/10.1016/s0268-9499(95)80003-4" @default.
- W1986648376 hasPublicationYear "1995" @default.
- W1986648376 type Work @default.
- W1986648376 sameAs 1986648376 @default.
- W1986648376 citedByCount "5" @default.
- W1986648376 crossrefType "journal-article" @default.
- W1986648376 hasAuthorship W1986648376A5016842679 @default.
- W1986648376 hasAuthorship W1986648376A5026903949 @default.
- W1986648376 hasAuthorship W1986648376A5056242060 @default.
- W1986648376 hasAuthorship W1986648376A5073815096 @default.
- W1986648376 hasConcept C126322002 @default.
- W1986648376 hasConcept C134018914 @default.
- W1986648376 hasConcept C17991360 @default.
- W1986648376 hasConcept C185592680 @default.
- W1986648376 hasConcept C203014093 @default.
- W1986648376 hasConcept C2776892390 @default.
- W1986648376 hasConcept C2778690821 @default.
- W1986648376 hasConcept C2779395532 @default.
- W1986648376 hasConcept C2779679481 @default.
- W1986648376 hasConcept C2780675426 @default.
- W1986648376 hasConcept C2992686903 @default.
- W1986648376 hasConcept C71924100 @default.
- W1986648376 hasConcept C74172505 @default.
- W1986648376 hasConcept C86803240 @default.
- W1986648376 hasConceptScore W1986648376C126322002 @default.
- W1986648376 hasConceptScore W1986648376C134018914 @default.
- W1986648376 hasConceptScore W1986648376C17991360 @default.
- W1986648376 hasConceptScore W1986648376C185592680 @default.
- W1986648376 hasConceptScore W1986648376C203014093 @default.
- W1986648376 hasConceptScore W1986648376C2776892390 @default.
- W1986648376 hasConceptScore W1986648376C2778690821 @default.
- W1986648376 hasConceptScore W1986648376C2779395532 @default.
- W1986648376 hasConceptScore W1986648376C2779679481 @default.
- W1986648376 hasConceptScore W1986648376C2780675426 @default.
- W1986648376 hasConceptScore W1986648376C2992686903 @default.
- W1986648376 hasConceptScore W1986648376C71924100 @default.
- W1986648376 hasConceptScore W1986648376C74172505 @default.
- W1986648376 hasConceptScore W1986648376C86803240 @default.
- W1986648376 hasIssue "3" @default.
- W1986648376 hasLocation W19866483761 @default.
- W1986648376 hasOpenAccess W1986648376 @default.
- W1986648376 hasPrimaryLocation W19866483761 @default.
- W1986648376 hasRelatedWork W1781372697 @default.
- W1986648376 hasRelatedWork W2007892966 @default.
- W1986648376 hasRelatedWork W2067682325 @default.
- W1986648376 hasRelatedWork W2078057762 @default.
- W1986648376 hasRelatedWork W2109584355 @default.
- W1986648376 hasRelatedWork W2110804417 @default.
- W1986648376 hasRelatedWork W2135642402 @default.
- W1986648376 hasRelatedWork W2152355615 @default.
- W1986648376 hasRelatedWork W2186224527 @default.
- W1986648376 hasRelatedWork W2460292361 @default.
- W1986648376 hasVolume "9" @default.
- W1986648376 isParatext "false" @default.
- W1986648376 isRetracted "false" @default.
- W1986648376 magId "1986648376" @default.
- W1986648376 workType "article" @default.