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- W1986656912 abstract "Structually diverse peroxisome-proliferators (PPs) were investigated regarding their effects on NAD + level and two key enzyme activities in the tryptophan (Trp)–NAD + pathway in the liver of rats (Sprague–Dawley male) fed PP-containing diets freely for 2 weeks. All PPs, except for thyroxine, significantly increased hepatic NAD + level in concert with hepatic hypertrophy. Activity of quinolinate phosphoribosyltransferase (QAPRTase), one of the key enzymes in the Trp–NAD + pathway, was increased by the PPs which caused significant increase in the hepatic NAD + . On the other hand, α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSDase), another key enzyme in the Trp–NAD + pathway, was drastically inhibited by all PPs except for linolenic acid, which was only slightly inhibitory. Most PPs investigated activated peroxisomal marker enzymes such as palmitoyl-CoA oxidase, catalase, and PPAR-α(peroxisome-proliferator activated receptor-α)-dependent enzymes, such as malic enzyme and l -3-glycerophosphate dehydrogenase. NAD + was also increased in the rat hepatocytes cultured in the medium supplemented with PPs. These data suggested that regulation of the key enzymes in the Trp–NAD + pathway was associated with PPAR-α directly or indirectly, and as a consequence the hepatic NAD + was increased by PPs." @default.
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- W1986656912 date "1999-07-01" @default.
- W1986656912 modified "2023-09-24" @default.
- W1986656912 title "Peroxisome-Proliferator Regulates Key Enzymes of the Tryptophan-NAD+ Pathway" @default.
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- W1986656912 doi "https://doi.org/10.1006/taap.1999.8683" @default.
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