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- W1986661009 abstract "Adverse lung effects following pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) are well documented in rodents. However, systemic effects are less understood. Epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particles, which has led to concerns that inhalation exposure to MWCNTs might pose similar risks. We analyzed parameters related to cardiovascular disease, including plasma acute phase response (APR) proteins and plasma lipids, in female C57BL/6 mice exposed to a single intratracheal instillation of 0, 18, 54 or 162 μg/mouse of small, entangled (CNTSmall, 0.8 ± 0.1 μm long) or large, thick MWCNTs (CNTLarge, 4 ± 0.4 μm long). Liver tissues and plasma were harvested 1, 3 and 28 days post-exposure. In addition, global hepatic gene expression, hepatic cholesterol content and liver histology were used to assess hepatic effects. The two MWCNTs induced similar systemic responses despite their different physicochemical properties. APR proteins SAA3 and haptoglobin, plasma total cholesterol and low-density/very low-density lipoprotein were significantly increased following exposure to either MWCNTs. Plasma SAA3 levels correlated strongly with pulmonary Saa3 levels. Analysis of global gene expression revealed perturbation of the same biological processes and pathways in liver, including the HMG-CoA reductase pathway. Both MWCNTs induced similar histological hepatic changes, with a tendency towards greater response following CNTLarge exposure. Overall, we show that pulmonary exposure to two different MWCNTs induces similar systemic and hepatic responses, including changes in plasma APR, lipid composition, hepatic gene expression and liver morphology. The results link pulmonary exposure to MWCNTs with risk of cardiovascular disease." @default.
- W1986661009 created "2016-06-24" @default.
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- W1986661009 date "2015-03-01" @default.
- W1986661009 modified "2023-10-16" @default.
- W1986661009 title "Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease" @default.
- W1986661009 cites W147019719 @default.
- W1986661009 cites W1483315176 @default.
- W1986661009 cites W1520348292 @default.
- W1986661009 cites W1950462993 @default.
- W1986661009 cites W1965480509 @default.
- W1986661009 cites W1966657551 @default.
- W1986661009 cites W1967239730 @default.
- W1986661009 cites W1969368124 @default.
- W1986661009 cites W1979072219 @default.
- W1986661009 cites W1983844880 @default.
- W1986661009 cites W1997981911 @default.
- W1986661009 cites W1998246284 @default.
- W1986661009 cites W2000011436 @default.
- W1986661009 cites W2005813970 @default.
- W1986661009 cites W2010264557 @default.
- W1986661009 cites W2010953549 @default.
- W1986661009 cites W2014083365 @default.
- W1986661009 cites W2018904844 @default.
- W1986661009 cites W2019300253 @default.
- W1986661009 cites W2019358153 @default.
- W1986661009 cites W2020302121 @default.
- W1986661009 cites W2027103457 @default.
- W1986661009 cites W2030955639 @default.
- W1986661009 cites W2031148890 @default.
- W1986661009 cites W2036508923 @default.
- W1986661009 cites W2037012230 @default.
- W1986661009 cites W2038944150 @default.
- W1986661009 cites W2040592634 @default.
- W1986661009 cites W2041895471 @default.
- W1986661009 cites W2042411173 @default.
- W1986661009 cites W2043548074 @default.
- W1986661009 cites W2046315474 @default.
- W1986661009 cites W2047925884 @default.
- W1986661009 cites W2052197963 @default.
- W1986661009 cites W2052971899 @default.
- W1986661009 cites W2057834556 @default.
- W1986661009 cites W2058610272 @default.
- W1986661009 cites W2059165000 @default.
- W1986661009 cites W2068498370 @default.
- W1986661009 cites W2071124826 @default.
- W1986661009 cites W2073579059 @default.
- W1986661009 cites W2076487225 @default.
- W1986661009 cites W2083559318 @default.
- W1986661009 cites W2083775683 @default.
- W1986661009 cites W2085725801 @default.
- W1986661009 cites W2087023256 @default.
- W1986661009 cites W2088004768 @default.
- W1986661009 cites W2088926876 @default.
- W1986661009 cites W2089929841 @default.
- W1986661009 cites W2093263374 @default.
- W1986661009 cites W2094166570 @default.
- W1986661009 cites W2095682295 @default.
- W1986661009 cites W2096673955 @default.
- W1986661009 cites W2099733654 @default.
- W1986661009 cites W2100026340 @default.
- W1986661009 cites W2100162281 @default.
- W1986661009 cites W2102346500 @default.
- W1986661009 cites W2104286517 @default.
- W1986661009 cites W2104777847 @default.
- W1986661009 cites W2111313885 @default.
- W1986661009 cites W2117537998 @default.
- W1986661009 cites W2121659530 @default.
- W1986661009 cites W2122889851 @default.
- W1986661009 cites W2124717298 @default.
- W1986661009 cites W2124915242 @default.
- W1986661009 cites W2126207677 @default.
- W1986661009 cites W2126736180 @default.
- W1986661009 cites W2130542796 @default.
- W1986661009 cites W2133465414 @default.
- W1986661009 cites W2138366706 @default.
- W1986661009 cites W2142979519 @default.
- W1986661009 cites W2145318781 @default.
- W1986661009 cites W2146137933 @default.
- W1986661009 cites W2146321139 @default.
- W1986661009 cites W2147181044 @default.
- W1986661009 cites W2148017011 @default.
- W1986661009 cites W2149777491 @default.
- W1986661009 cites W2150691772 @default.
- W1986661009 cites W2155924874 @default.
- W1986661009 cites W2158217645 @default.
- W1986661009 cites W2159904710 @default.