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- W1986661505 abstract "Purpose TNMD is an X-chromosomal gene, which encodes a putative angiogenesis inhibitor, a type II transmembrane glycoprotein, which has proven to be expressed in retina. Associations of single nucleotide polymorphisms of TNMD with the prevalence of age-related macular degeneration (AMD) was examined. Methods The study population comprised of 38 men and 65 women with exudative AMD, 16 men and 23 women with dry AMD and 35 men and 75 women without AMD (controls). Patients with choroidal neovascularization attributable to AMD were diagnosed by fundus photographs and fluorescein angiography in the Department of Ophthalmology at Kuopio University Hospital. There were no signs of AMD in the control group as visualized in fundus photographs. In both groups, selection criteria required subjects to be over 65 years of age and diabetes mellitus was considered an exclusion criterion. Results Men with rs5966709-G genotype had higher prevalence of AMD (exudative and dry form combined) than subjects with rs5966709-T-genotype (69% vs 47%, p=0.045). However, the difference in the prevalence of exudative and dry form of AMD was not statistically significant (p=0.061, p=0.179). Among women the subjects with rs2073163-CT-genotype had lower prevalence (28%) of exudative form of AMD than other genotypes (49% and 59% for subjects with rs2073163-CC- and rs2073163-TT-genotypes, correspondingly, p=0.028). Conclusion The rs5966709-G genotype of TNMD is a modest AMD risk factor for men, while rs2073163-CT-genotype might be protective for women in exudative AMD." @default.
- W1986661505 created "2016-06-24" @default.
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- W1986661505 date "2008-09-04" @default.
- W1986661505 modified "2023-09-23" @default.
- W1986661505 title "Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration" @default.
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- W1986661505 doi "https://doi.org/10.1111/j.1755-3768.2008.472.x" @default.
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