Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986668810> ?p ?o ?g. }
- W1986668810 endingPage "37" @default.
- W1986668810 startingPage "27" @default.
- W1986668810 abstract "We have generated transgenic mice harboring the murine matrix metalloproteinase 9 (MMP-9) promoter cloned in front of human TIMP-1 cDNA. The transgenic mice were viable and fertile and exhibited normal growth and general development. During wound healing the mice were shown to express human TIMP-1 in keratinocytes that normally express MMP-9. However, the healing of skin wounds was significantly retarded with slow migration of keratinocytes over the wound in transgenic mice. In situ zymography carried out on wound tissues revealed total blockage of gelatinolytic activity (i.e., MMP-9 and MMP-2). The results confirm studies with MMP-9 knockout mice showing that MMP-9 is not essential for general development, but they also demonstrate an important role of keratinocyte MMP-9, as well that of other keratinocyte MMPs that are inhibited by TIMP-1, in wound healing. The transgenic mice generated in this study provide a model for the role of MMPs in MMP-9-producing cells in other challenging situations such as bone fracture recovery and cancer invasion." @default.
- W1986668810 created "2016-06-24" @default.
- W1986668810 creator A5000224317 @default.
- W1986668810 creator A5002651600 @default.
- W1986668810 creator A5010312994 @default.
- W1986668810 creator A5023952028 @default.
- W1986668810 creator A5026327651 @default.
- W1986668810 creator A5068133733 @default.
- W1986668810 creator A5068797534 @default.
- W1986668810 date "2004-01-01" @default.
- W1986668810 modified "2023-10-16" @default.
- W1986668810 title "Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice" @default.
- W1986668810 cites W148052990 @default.
- W1986668810 cites W1484163259 @default.
- W1986668810 cites W1503393361 @default.
- W1986668810 cites W1545521314 @default.
- W1986668810 cites W1569577235 @default.
- W1986668810 cites W1576210721 @default.
- W1986668810 cites W1599093134 @default.
- W1986668810 cites W1602981281 @default.
- W1986668810 cites W1664158328 @default.
- W1986668810 cites W1882307056 @default.
- W1986668810 cites W1886431664 @default.
- W1986668810 cites W1894541755 @default.
- W1986668810 cites W1943923258 @default.
- W1986668810 cites W1975775157 @default.
- W1986668810 cites W1976068877 @default.
- W1986668810 cites W1979390430 @default.
- W1986668810 cites W1987542353 @default.
- W1986668810 cites W1996647701 @default.
- W1986668810 cites W1996935665 @default.
- W1986668810 cites W2001232517 @default.
- W1986668810 cites W2003262128 @default.
- W1986668810 cites W2004307784 @default.
- W1986668810 cites W2006460272 @default.
- W1986668810 cites W2011807008 @default.
- W1986668810 cites W2014001027 @default.
- W1986668810 cites W2015031004 @default.
- W1986668810 cites W2016411107 @default.
- W1986668810 cites W2024602261 @default.
- W1986668810 cites W2024794839 @default.
- W1986668810 cites W2028147193 @default.
- W1986668810 cites W2029347297 @default.
- W1986668810 cites W2029782642 @default.
- W1986668810 cites W2036017138 @default.
- W1986668810 cites W2043629174 @default.
- W1986668810 cites W2046280437 @default.
- W1986668810 cites W2051005256 @default.
- W1986668810 cites W2056105344 @default.
- W1986668810 cites W2068770705 @default.
- W1986668810 cites W2070132491 @default.
- W1986668810 cites W2074409617 @default.
- W1986668810 cites W2082081846 @default.
- W1986668810 cites W2083294270 @default.
- W1986668810 cites W2096788411 @default.
- W1986668810 cites W2101189183 @default.
- W1986668810 cites W2102164012 @default.
- W1986668810 cites W2118837944 @default.
- W1986668810 cites W2128049766 @default.
- W1986668810 cites W2136934871 @default.
- W1986668810 cites W2183019695 @default.
- W1986668810 cites W2412991340 @default.
- W1986668810 cites W2654488637 @default.
- W1986668810 doi "https://doi.org/10.1007/s00441-003-0814-1" @default.
- W1986668810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14569458" @default.
- W1986668810 hasPublicationYear "2004" @default.
- W1986668810 type Work @default.
- W1986668810 sameAs 1986668810 @default.
- W1986668810 citedByCount "37" @default.
- W1986668810 countsByYear W19866688102012 @default.
- W1986668810 countsByYear W19866688102013 @default.
- W1986668810 countsByYear W19866688102014 @default.
- W1986668810 countsByYear W19866688102017 @default.
- W1986668810 countsByYear W19866688102018 @default.
- W1986668810 countsByYear W19866688102019 @default.
- W1986668810 countsByYear W19866688102022 @default.
- W1986668810 countsByYear W19866688102023 @default.
- W1986668810 crossrefType "journal-article" @default.
- W1986668810 hasAuthorship W1986668810A5000224317 @default.
- W1986668810 hasAuthorship W1986668810A5002651600 @default.
- W1986668810 hasAuthorship W1986668810A5010312994 @default.
- W1986668810 hasAuthorship W1986668810A5023952028 @default.
- W1986668810 hasAuthorship W1986668810A5026327651 @default.
- W1986668810 hasAuthorship W1986668810A5068133733 @default.
- W1986668810 hasAuthorship W1986668810A5068797534 @default.
- W1986668810 hasBestOaLocation W19866688102 @default.
- W1986668810 hasConcept C102230213 @default.
- W1986668810 hasConcept C104317684 @default.
- W1986668810 hasConcept C109523444 @default.
- W1986668810 hasConcept C141035611 @default.
- W1986668810 hasConcept C153911025 @default.
- W1986668810 hasConcept C170493617 @default.
- W1986668810 hasConcept C177430391 @default.
- W1986668810 hasConcept C182704531 @default.
- W1986668810 hasConcept C203014093 @default.
- W1986668810 hasConcept C2777074287 @default.
- W1986668810 hasConcept C2780269544 @default.
- W1986668810 hasConcept C502942594 @default.