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• W1986670260 abstract "DNAase footprint analyses of purified AD2 + D2 (D2) T protein binding to simian virus 40 origin region fragments revealed a series of four specific interactions with contiguous sequences constituting a 120 base-pair block, in keeping with previous DNAase protection results reported by others. Protection was observed to extend from a 30 base-pair strong affinity site located on the early side of the replication origin (site 1) to two adjacent lower affinity sites, including the origin of replication (site 2) and a 11 to 13 base-pair site between site 1 and the beginning of the T/t coding sequence (site 1′). A fourth site (site 3) was noted abutting the late border of site 2. Binding to site 1 was associated with enhanced D2T binding to sites 2 and 1′. Thus, binding to these sites is co-operative and/or the sequences which constitute site 1 affect the conformation of the sites 1′ and 2 sequences such that they now serve as sites of more efficient D2T binding. In addition, while deletion of all of site 2 and its substitution by late viral sequences ablated processive T binding to sequences abutting site 1 on its late side, various site 2 deletions comprising up to approximately 40% of that sequence did not affect binding to that site to a major degree. Therefore, binding to the replication origin is a sequence-specific event, but there may be multiple strong protein contact sites within that sequence." @default.
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• W1986670260 date "1982-05-01" @default.
• W1986670260 modified "2023-09-23" @default.
• W1986670260 title "Binding of an analog of the simian virus 40 T antigen to wild-type and mutant viral replication origins" @default.
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• W1986670260 doi "https://doi.org/10.1016/0022-2836(82)90472-7" @default.
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