FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986677506> ?p ?o ?g. }

• W1986677506 endingPage "331" @default.
• W1986677506 startingPage "324" @default.
• W1986677506 abstract "To better understand neurochemical and psychopharmacological aspects of post-traumatic stress disorder (PTSD), it is necessary establish an animal model of PTSD in which behavioral changes persist for a long time after the initial traumatization. The present study aimed to characterize long-term behavioral alterations in male ICR mice as an animal model of PTSD consisting of a 2-day foot shock (0.8 mA, 10 s) followed by 3 weekly situational reminders (SR), and to evaluate the effects of repeated administration of valproate and diazepam on behavioral deficits of this animal model. The results showed that the aversive procedure induced several long-term behavioral deficiencies: increased freezing behavior and anxiety level, reduced time spent in an aversive like context. Repeated treatment with valproate (100-400 mg/kg, i.p.) induced a dose-dependent reduction of these behavioral changes. In contrast, diazepam at a low dose (0.25 mg/kg) but not at a high dose (4 mg/kg) reduced the behavioral deficiencies. These results demonstrate that exposure to intense foot shock associated with repeated situational reminders elicits long-term disturbances that last about 4 weeks after the foot shock exposure. These behavioral deficits can be ameliorated by repeated administration of valproate or diazepam at some special dose ranges." @default.
• W1986677506 created "2016-06-24" @default.
• W1986677506 creator A5036883729 @default.
• W1986677506 creator A5057672918 @default.
• W1986677506 creator A5061062138 @default.
• W1986677506 creator A5090796794 @default.
• W1986677506 creator A5091395731 @default.
• W1986677506 date "2006-10-01" @default.
• W1986677506 modified "2023-09-27" @default.
• W1986677506 title "The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder" @default.
• W1986677506 cites W139473238 @default.
• W1986677506 cites W147037372 @default.
• W1986677506 cites W1808156981 @default.
• W1986677506 cites W1966923418 @default.
• W1986677506 cites W1968638036 @default.
• W1986677506 cites W1975875551 @default.
• W1986677506 cites W1983144777 @default.
• W1986677506 cites W1987165014 @default.
• W1986677506 cites W1995503035 @default.
• W1986677506 cites W2011110841 @default.
• W1986677506 cites W2011893712 @default.
• W1986677506 cites W2013871694 @default.
• W1986677506 cites W2027914056 @default.
• W1986677506 cites W2034517065 @default.
• W1986677506 cites W2035592268 @default.
• W1986677506 cites W2036981832 @default.
• W1986677506 cites W2041561931 @default.
• W1986677506 cites W2058413487 @default.
• W1986677506 cites W2062642133 @default.
• W1986677506 cites W2062682953 @default.
• W1986677506 cites W2063112284 @default.
• W1986677506 cites W2068922657 @default.
• W1986677506 cites W2069219436 @default.
• W1986677506 cites W2070971788 @default.
• W1986677506 cites W2072435021 @default.
• W1986677506 cites W2075091333 @default.
• W1986677506 cites W2076781188 @default.
• W1986677506 cites W2080698496 @default.
• W1986677506 cites W2084178646 @default.
• W1986677506 cites W2086716437 @default.
• W1986677506 cites W2088962983 @default.
• W1986677506 cites W2090019039 @default.
• W1986677506 cites W2090310975 @default.
• W1986677506 cites W2090875152 @default.
• W1986677506 cites W2098070616 @default.
• W1986677506 cites W2107367352 @default.
• W1986677506 cites W2121651624 @default.
• W1986677506 cites W2126506589 @default.
• W1986677506 cites W2134015193 @default.
• W1986677506 cites W2143438415 @default.
• W1986677506 cites W2154287369 @default.
• W1986677506 cites W2159011576 @default.
• W1986677506 cites W2166581738 @default.
• W1986677506 cites W2205487821 @default.
• W1986677506 cites W2412013403 @default.
• W1986677506 cites W2416416704 @default.
• W1986677506 cites W2466225796 @default.
• W1986677506 cites W794376169 @default.
• W1986677506 cites W83677019 @default.
• W1986677506 doi "https://doi.org/10.1016/j.pbb.2006.08.015" @default.
• W1986677506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17034840" @default.
• W1986677506 hasPublicationYear "2006" @default.
• W1986677506 type Work @default.
• W1986677506 sameAs 1986677506 @default.
• W1986677506 citedByCount "55" @default.
• W1986677506 countsByYear W19866775062012 @default.
• W1986677506 countsByYear W19866775062013 @default.
• W1986677506 countsByYear W19866775062014 @default.
• W1986677506 countsByYear W19866775062015 @default.
• W1986677506 countsByYear W19866775062016 @default.
• W1986677506 countsByYear W19866775062017 @default.
• W1986677506 countsByYear W19866775062018 @default.
• W1986677506 countsByYear W19866775062019 @default.
• W1986677506 countsByYear W19866775062020 @default.
• W1986677506 countsByYear W19866775062021 @default.
• W1986677506 countsByYear W19866775062022 @default.
• W1986677506 countsByYear W19866775062023 @default.
• W1986677506 crossrefType "journal-article" @default.
• W1986677506 hasAuthorship W1986677506A5036883729 @default.
• W1986677506 hasAuthorship W1986677506A5057672918 @default.
• W1986677506 hasAuthorship W1986677506A5061062138 @default.
• W1986677506 hasAuthorship W1986677506A5090796794 @default.
• W1986677506 hasAuthorship W1986677506A5091395731 @default.
• W1986677506 hasConcept C118552586 @default.
• W1986677506 hasConcept C126322002 @default.
• W1986677506 hasConcept C151730666 @default.
• W1986677506 hasConcept C15744967 @default.
• W1986677506 hasConcept C169760540 @default.
• W1986677506 hasConcept C25876315 @default.
• W1986677506 hasConcept C2776175493 @default.
• W1986677506 hasConcept C2778117688 @default.
• W1986677506 hasConcept C2779343474 @default.
• W1986677506 hasConcept C42219234 @default.
• W1986677506 hasConcept C558461103 @default.
• W1986677506 hasConcept C71924100 @default.
• W1986677506 hasConcept C86803240 @default.
• W1986677506 hasConceptScore W1986677506C118552586 @default.
• W1986677506 hasConceptScore W1986677506C126322002 @default.

• next