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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986678401> ?p ?o ?g. }

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• W1986678401 abstract "Abstract The aim of this study is to investigate on human skin the role of the cellular recovery, progression in the cell cycle and repopulation during a fractionated irradiation. We have determined the dose increment D r = 2 D s -D s to be added when a single dose D s is replaced by two equal doses D i at an interval i, for doses ranging from 2 x 150 rads to 2 x 850 rads and time intervals ranging from 1 hr to 4 days. For i = 6 hr, D r is less than 300 rads for D i = 850 rads; it diminishes with D i and becomes very small for doses D i below 200 rads. Assuming that for this time interval; D r is mainly related to cellular recovery from sublethal injuries (Elkind recovery), this latter mechanism seems to become important only for large doses of several hundred rads. The experimental data are only compatible with a two-component cell model in which a great part of the cell killing is due to lethal events; cell killing by accumulation of sublethal events seems to be of minor importance for the usual doses per fraction in radiotherapy. The variation of D r for intervals ranging from 6 hr to 4 days is attributed to the variation of sensitivity to progression in cell cycle. For D i = 850 rads, D r reaches a maximum (400 rads) at 48 hr. From the experimental data one can compute the dose increase associated with increasing number of fraction. By comparison with the usual iso effect relationship (Strandqvist's type) one can derive the role of repopulation associated to the overall time of treatment: repopulation rate has been found equivalent to 30–40 rads/day. It is concluded that, under usual regimes of radiotherapy, when the number of fractions and overall time are simultaneously increased, the dose increase is mainly associated to cellular recovery if the number of fractions it small (i.e. if the dose per fraclion is large), and to repopulation when the dose per fraction becomes small, i.e. practically when the number of fractions exceeds 15." @default.
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• W1986678401 date "1973-03-01" @default.
• W1986678401 modified "2023-09-23" @default.
• W1986678401 title "Cellular recovery in human skin reactions: Application to dose fraction number overall time relationship in radiotherapy" @default.
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• W1986678401 doi "https://doi.org/10.1016/s0014-2964(73)80014-3" @default.
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