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• W1986683721 abstract "Osteoporosis, characterized by excessive osteoclast mediated bone resorption, affects millions of people worldwide representing a major public health problem. ClC-7 is a chloride-proton exchanger localized in lysosomes and in the resorption lacuna in osteoclasts where it is essential for bone resorption. Thus, drugs targeted at ClC-7 have been proposed for ameliorating osteoporosis. However, functional assays suited for high throughput screening (HTS) of ClC-7 function are lacking. Here we describe two complementary variants of purely optical assays of the transport activity of ClC-7, redirected to the plasma membrane employing a genetically encoded fluorescent Cl⁻/pH indicator fused to the ClC-7 protein. These simple and robust functional assays of ClC-7 transport are well-suited to be applied in HTS of small-molecule inhibitors and may help to develop drugs suited for the treatment of osteoporosis." @default.
• W1986683721 created "2016-06-24" @default.
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• W1986683721 date "2013-02-06" @default.
• W1986683721 modified "2023-10-14" @default.
• W1986683721 title "An optical assay of the transport activity of ClC-7" @default.
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• W1986683721 doi "https://doi.org/10.1038/srep01231" @default.
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