FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986688294> ?p ?o ?g. }

• W1986688294 endingPage "277" @default.
• W1986688294 startingPage "271" @default.
• W1986688294 abstract "Islet amyloid polypeptide (IAPP or amylin) is costored and cosecreted with insulin and may regulate insulin secretion and blood glucose handling. However, the role and importance of endogenous IAPP in the regulation of insulin release and glucose homeostasis have been controversial. Here we report on the generation and phenotypic analysis of IAPP-deficient mice. These mice have normal, or near to normal, basal levels of circulating insulin and glucose. However, following glucose administration, IAPP-deficient males presented increased insulin responses paralleled with a more rapid blood glucose elimination compared to wild-type controls. Blood glucose elimination was also found to be enhanced in IAPP-deficient females, but the insulin response in this gender did not differ from controls. In a transgenic rescue experiment, using an insulin-promoter human-IAPP fusion gene, insulin responses and blood glucose elimination were reversed in IAPP-deficient males, whereas the female phenotype appeared unaffected. Our results provide the first firm evidence of a physiological role for endogenous IAPP and indicate that IAPP, apparently in a gender-dependent manner, limits the degree of glucose-induced insulin secretion and the rate of blood glucose elimination." @default.
• W1986688294 created "2016-06-24" @default.
• W1986688294 creator A5008503582 @default.
• W1986688294 creator A5014848806 @default.
• W1986688294 creator A5027109387 @default.
• W1986688294 creator A5028156723 @default.
• W1986688294 creator A5051005847 @default.
• W1986688294 creator A5075368078 @default.
• W1986688294 creator A5078058223 @default.
• W1986688294 creator A5089409786 @default.
• W1986688294 creator A5090331352 @default.
• W1986688294 date "1998-09-01" @default.
• W1986688294 modified "2023-10-18" @default.
• W1986688294 title "Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin)" @default.
• W1986688294 cites W1497697894 @default.
• W1986688294 cites W1964576674 @default.
• W1986688294 cites W1965264273 @default.
• W1986688294 cites W1967006902 @default.
• W1986688294 cites W1972371265 @default.
• W1986688294 cites W1975696039 @default.
• W1986688294 cites W1977150735 @default.
• W1986688294 cites W1977574157 @default.
• W1986688294 cites W1981578013 @default.
• W1986688294 cites W1982661346 @default.
• W1986688294 cites W1986338276 @default.
• W1986688294 cites W1986729906 @default.
• W1986688294 cites W1987293314 @default.
• W1986688294 cites W1993205343 @default.
• W1986688294 cites W1994056464 @default.
• W1986688294 cites W2004210837 @default.
• W1986688294 cites W2009837365 @default.
• W1986688294 cites W2015543318 @default.
• W1986688294 cites W2032348784 @default.
• W1986688294 cites W2034072206 @default.
• W1986688294 cites W2034109892 @default.
• W1986688294 cites W2034644920 @default.
• W1986688294 cites W2044806682 @default.
• W1986688294 cites W2045466835 @default.
• W1986688294 cites W2049409248 @default.
• W1986688294 cites W2050367709 @default.
• W1986688294 cites W2056007483 @default.
• W1986688294 cites W2067820229 @default.
• W1986688294 cites W2068202200 @default.
• W1986688294 cites W2069723292 @default.
• W1986688294 cites W2090172582 @default.
• W1986688294 cites W2092435609 @default.
• W1986688294 cites W2093289749 @default.
• W1986688294 cites W2110153861 @default.
• W1986688294 cites W2113752311 @default.
• W1986688294 cites W2132324413 @default.
• W1986688294 cites W2151702699 @default.
• W1986688294 cites W2159489160 @default.
• W1986688294 cites W2165886858 @default.
• W1986688294 doi "https://doi.org/10.1006/bbrc.1998.9308" @default.
• W1986688294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9753619" @default.
• W1986688294 hasPublicationYear "1998" @default.
• W1986688294 type Work @default.
• W1986688294 sameAs 1986688294 @default.
• W1986688294 citedByCount "148" @default.
• W1986688294 countsByYear W19866882942012 @default.
• W1986688294 countsByYear W19866882942013 @default.
• W1986688294 countsByYear W19866882942014 @default.
• W1986688294 countsByYear W19866882942015 @default.
• W1986688294 countsByYear W19866882942016 @default.
• W1986688294 countsByYear W19866882942017 @default.
• W1986688294 countsByYear W19866882942018 @default.
• W1986688294 countsByYear W19866882942019 @default.
• W1986688294 countsByYear W19866882942020 @default.
• W1986688294 countsByYear W19866882942021 @default.
• W1986688294 countsByYear W19866882942022 @default.
• W1986688294 countsByYear W19866882942023 @default.
• W1986688294 crossrefType "journal-article" @default.
• W1986688294 hasAuthorship W1986688294A5008503582 @default.
• W1986688294 hasAuthorship W1986688294A5014848806 @default.
• W1986688294 hasAuthorship W1986688294A5027109387 @default.
• W1986688294 hasAuthorship W1986688294A5028156723 @default.
• W1986688294 hasAuthorship W1986688294A5051005847 @default.
• W1986688294 hasAuthorship W1986688294A5075368078 @default.
• W1986688294 hasAuthorship W1986688294A5078058223 @default.
• W1986688294 hasAuthorship W1986688294A5089409786 @default.
• W1986688294 hasAuthorship W1986688294A5090331352 @default.
• W1986688294 hasConcept C102230213 @default.
• W1986688294 hasConcept C104317684 @default.
• W1986688294 hasConcept C126322002 @default.
• W1986688294 hasConcept C134018914 @default.
• W1986688294 hasConcept C141035611 @default.
• W1986688294 hasConcept C144855686 @default.
• W1986688294 hasConcept C165220095 @default.
• W1986688294 hasConcept C16613235 @default.
• W1986688294 hasConcept C2777391703 @default.
• W1986688294 hasConcept C2777633098 @default.
• W1986688294 hasConcept C2778024521 @default.
• W1986688294 hasConcept C2779306644 @default.
• W1986688294 hasConcept C2780705028 @default.
• W1986688294 hasConcept C3018667095 @default.
• W1986688294 hasConcept C55493867 @default.
• W1986688294 hasConcept C59822182 @default.
• W1986688294 hasConcept C63645605 @default.

• next