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• W1986691597 abstract "[ 18 F]fallyprlde is a high-affinity dopamine D2/3 receptor tracer with the ability to reliably quantify D2/3 receptor sites in both striatal and corticolimbic regions. The translational potential of [ 18 F]fallypride imaging is, however, limited by the lengthy scanning sessions (60–80 minutes duration over a total of 3–4 hours) required by current protocols. The aims of our study were to adapt [ 18 F]fallypride imaging for use in clinical populations with neurological and neuropsychiatric disorders, by reducing the duration of individual scanning sessions;and to establish the reproducibility and reliability of our adapted protocol in healthy older people. Eight participants (five male and three female;mean age = 75.87 ± 4.39 years) were scanned twice, 4–6 weeks apart. [ 18 F]fallypride binding potential was determined from image data collected during three sampling times: 0-30;60-90;and 210–240 minutes post injection. High reproducibility and reliability (test-retest variability <8%;intraclass correlation coefficient >0.8) were observed in all but the prefrontal regions, and remained so when sampling times were reduced to 20 minutes (0-20;70-90;220-240 minutes). The adapted protocol is feasible for use across neuropsychiatric disorders in which dopamine has been implicated and is sufficiently sensitive to detect within-subject changes between 2.7% and 5.5% in striatal and limbic regions." @default.
• W1986691597 created "2016-06-24" @default.
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• W1986691597 date "2013-04-17" @default.
• W1986691597 modified "2023-10-14" @default.
• W1986691597 title "Establishing Test–Retest Reliability of an Adapted [¹⁸F]Fallypride Imaging Protocol in Older People" @default.
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• W1986691597 doi "https://doi.org/10.1038/jcbfm.2013.55" @default.
• W1986691597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3705439" @default.
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