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- W1986692013 abstract "Abstract Administration of thioacetamide in a dose of 50 mg/kg body wt./day results in an increase in the alkaline ribonuclease activity of rat liver paniculate fractions. There is a change in the distribution of the enzyme among these fractions inasmuch as the total ribonuclease in the lysosomal fraction remained constant or decreased while the ribonuclease in the nuclear, mitochondrial, and microsomal fractions markedly increased. A decrease in the amount of ‘latent’ ribonuclease was found in the cytoplasmic particulate fractions. No concomitant increase in phosphodiesterase activity could be detected. It was established earlier 1,2 that the increased ribonuclease activity in the hepatic nuclei and nucleoli after thioacetamide treatment is not simply an accompaniment of increased nuclear size. The present study indicates that in the thioacetamide-treated liver, the augmented ribonuclease activity in the paniculate fractions is associated with a decrease in the concentration of ribonuclease inhibitor in the cell-free supernatant fraction." @default.
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- W1986692013 date "1967-09-01" @default.
- W1986692013 modified "2023-09-25" @default.
- W1986692013 title "Effect of thiocetamide on the activity of alkaline ribonuclease and ribonuclease inhibitor in rat liver" @default.
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- W1986692013 doi "https://doi.org/10.1016/0006-2952(67)90246-8" @default.
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