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- W1986699426 abstract "Three granulations of a fairly water-soluble high-dosage drug, dinatrium 3,3'-azobis(6-hydroxybenzoate), were produced by intensive mixing with polyvinylpyrrolidone, dissolved in three liquids with different amounts of ethanol and water, as binder. The granulations were mixed with dry binders or with a lubricant and granulations and mixtures were compressed at 300 MPa and the tablet strength was measured. The tablet strength increased with increased amount of ethanol in the binder solution. The increase and decrease in tablet strength due to the addition of dry binder and lubricant, respectively, were also dependent on the amount of ethanol in the binder solution and indicated that the degree of fragmentation varied between the granulations. Heckel plots and tablet surface area-compaction pressure profiles confirmed the finding that the degree of fragmentation of the granules increased with increasing amount of ethanol in the binder solution. A good correlation between fragmentation propensity of the granulations and tensile strength of the tablets was found." @default.
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- W1986699426 date "1987-06-01" @default.
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- W1986699426 title "Compression characteristics of granulated materials. I. Fragmentation propensity and compactibility of some granulations of a high dosage drug" @default.
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- W1986699426 doi "https://doi.org/10.1016/0378-5173(87)90020-2" @default.
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