Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986702985> ?p ?o ?g. }
- W1986702985 endingPage "3905" @default.
- W1986702985 startingPage "3898" @default.
- W1986702985 abstract "Abstract The translocation t(12;22) involves MN1 and TEL and is rarely found in acute myeloid leukemia (AML). Recently, it has been shown in a mouse model that the fusion protein MN1-TEL can promote growth of primitive hematopoietic progenitor cells (HPCs) and, in cooperation with HOXA9, induce AML. We quantified MN1 expression by real-time reverse transcriptase–polymerase chain reaction (RT-PCR) in 142 adult patients with AML with normal cytogenetics treated uniformly in trial AML-SHG 01/99. AML samples were dichotomized at the median MN1 expression. High MN1 expression was significantly correlated with unmutated NPM1 (P < .001), poor response to the first course of induction treatment (P = .02), a higher relapse rate (P = .03), and shorter relapse-free (P = .002) and overall survivals (P = .03). In multivariate analysis, MN1 expression was an independent prognostic marker (P = .02) in addition to age and Eastern Cooperative Oncology Group (ECOG) performance status. Excluding patients with NPM1mutated/FLT3ITDnegative, high MN1 expression was associated with shorter relapse-free survival (P = .057). MN1 was highly expressed in some patients with acute lymphoblastic but not chronic lymphocytic or myeloid leukemia. MN1 was highly expressed in HPCs compared with differentiated cells and was down-regulated during in vitro differentiation of CD34+ cells, suggesting a functional role in HPCs. In conclusion, our data suggest MN1 overexpression as a new prognostic marker in AML with normal cytogenetics." @default.
- W1986702985 created "2016-06-24" @default.
- W1986702985 creator A5013231760 @default.
- W1986702985 creator A5023422397 @default.
- W1986702985 creator A5031540176 @default.
- W1986702985 creator A5043723659 @default.
- W1986702985 creator A5053578678 @default.
- W1986702985 creator A5053983155 @default.
- W1986702985 creator A5089106575 @default.
- W1986702985 date "2006-12-01" @default.
- W1986702985 modified "2023-09-30" @default.
- W1986702985 title "High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics" @default.
- W1986702985 cites W1493021534 @default.
- W1986702985 cites W1736764851 @default.
- W1986702985 cites W1965584494 @default.
- W1986702985 cites W1973046493 @default.
- W1986702985 cites W1975956153 @default.
- W1986702985 cites W1978926685 @default.
- W1986702985 cites W2006116919 @default.
- W1986702985 cites W2009837903 @default.
- W1986702985 cites W2018080036 @default.
- W1986702985 cites W2018755464 @default.
- W1986702985 cites W2026414440 @default.
- W1986702985 cites W2038750132 @default.
- W1986702985 cites W2041027929 @default.
- W1986702985 cites W2041150576 @default.
- W1986702985 cites W2048565227 @default.
- W1986702985 cites W2056777862 @default.
- W1986702985 cites W2068311105 @default.
- W1986702985 cites W2106194243 @default.
- W1986702985 cites W2106473110 @default.
- W1986702985 cites W2109363337 @default.
- W1986702985 cites W2124041794 @default.
- W1986702985 cites W2129291113 @default.
- W1986702985 cites W2129345638 @default.
- W1986702985 cites W2129615499 @default.
- W1986702985 cites W2132912591 @default.
- W1986702985 cites W2140807655 @default.
- W1986702985 cites W2141324982 @default.
- W1986702985 cites W2142961359 @default.
- W1986702985 cites W2143297156 @default.
- W1986702985 cites W2143740614 @default.
- W1986702985 cites W2147418781 @default.
- W1986702985 cites W2147751870 @default.
- W1986702985 cites W2150113701 @default.
- W1986702985 cites W2153556422 @default.
- W1986702985 cites W2159170728 @default.
- W1986702985 cites W2159507916 @default.
- W1986702985 cites W2162309072 @default.
- W1986702985 cites W2170515966 @default.
- W1986702985 cites W2171482205 @default.
- W1986702985 cites W2274125263 @default.
- W1986702985 cites W227961483 @default.
- W1986702985 cites W2326585954 @default.
- W1986702985 cites W3147894994 @default.
- W1986702985 doi "https://doi.org/10.1182/blood-2006-04-014845" @default.
- W1986702985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16912223" @default.
- W1986702985 hasPublicationYear "2006" @default.
- W1986702985 type Work @default.
- W1986702985 sameAs 1986702985 @default.
- W1986702985 citedByCount "218" @default.
- W1986702985 countsByYear W19867029852012 @default.
- W1986702985 countsByYear W19867029852013 @default.
- W1986702985 countsByYear W19867029852014 @default.
- W1986702985 countsByYear W19867029852015 @default.
- W1986702985 countsByYear W19867029852016 @default.
- W1986702985 countsByYear W19867029852017 @default.
- W1986702985 countsByYear W19867029852018 @default.
- W1986702985 countsByYear W19867029852019 @default.
- W1986702985 countsByYear W19867029852020 @default.
- W1986702985 countsByYear W19867029852021 @default.
- W1986702985 countsByYear W19867029852022 @default.
- W1986702985 countsByYear W19867029852023 @default.
- W1986702985 crossrefType "journal-article" @default.
- W1986702985 hasAuthorship W1986702985A5013231760 @default.
- W1986702985 hasAuthorship W1986702985A5023422397 @default.
- W1986702985 hasAuthorship W1986702985A5031540176 @default.
- W1986702985 hasAuthorship W1986702985A5043723659 @default.
- W1986702985 hasAuthorship W1986702985A5053578678 @default.
- W1986702985 hasAuthorship W1986702985A5053983155 @default.
- W1986702985 hasAuthorship W1986702985A5089106575 @default.
- W1986702985 hasConcept C10205521 @default.
- W1986702985 hasConcept C104317684 @default.
- W1986702985 hasConcept C109159458 @default.
- W1986702985 hasConcept C126322002 @default.
- W1986702985 hasConcept C138626823 @default.
- W1986702985 hasConcept C143998085 @default.
- W1986702985 hasConcept C174475383 @default.
- W1986702985 hasConcept C201750760 @default.
- W1986702985 hasConcept C203014093 @default.
- W1986702985 hasConcept C2483381 @default.
- W1986702985 hasConcept C2778461978 @default.
- W1986702985 hasConcept C2778729363 @default.
- W1986702985 hasConcept C2779282312 @default.
- W1986702985 hasConcept C28328180 @default.
- W1986702985 hasConcept C30481170 @default.
- W1986702985 hasConcept C502942594 @default.
- W1986702985 hasConcept C53226629 @default.