FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986703630> ?p ?o ?g. }

• W1986703630 endingPage "224" @default.
• W1986703630 startingPage "222" @default.
• W1986703630 abstract "C-reactive protein (CRP), an inflammatory marker, was linked to coronary heart disease (CHD) in the Reykjavik study cohort. Recent genetic studies have shown that the apolipoprotein E (APOE) epsilon4 allele is associated with lower CRP levels. Statin treatment has also been shown to lower CRP levels. In the Age Gene/Environment Susceptibility (AGES)-Reykjavik Study, we examined the association of APOE genotypes with CRP accounting for the effect of statin treatment, previous CHD and a mid-life measurement of erythrocyte sedimentation rate (ESR), an inflammatory marker associated with risk in this cohort.The first 2296 participants (mean age 76+/-6 years, 42% men) in the AGES-Reykjavik Study were genotyped for APOE CRP concentration was measured with a high sensitivity method. A general linear model was used to evaluate the association of APOE genotype to CRP levels. The frequencies of the APOE alleles are epsilon2=0.06, epsilon3=0.78 and epsilon4=0.16. CRP levels ranged from 0.2 to 56.6 mg/L, median 1.9 mg/L. Participants carrying one or two epsilon4 alleles have significantly lower CRP levels than non-carriers and this effect was observed in a dose-dependent manner. This trend is the same in users and non-users of statin treatment.This study suggests that the contribution of the epsilon4 allele towards lowering CRP levels is independent and may be by a different mechanism than how statins affect inflammation." @default.
• W1986703630 created "2016-06-24" @default.
• W1986703630 creator A5000325789 @default.
• W1986703630 creator A5009252391 @default.
• W1986703630 creator A5018378907 @default.
• W1986703630 creator A5018722034 @default.
• W1986703630 creator A5020734267 @default.
• W1986703630 creator A5057919043 @default.
• W1986703630 creator A5072295805 @default.
• W1986703630 date "2006-05-01" @default.
• W1986703630 modified "2023-10-16" @default.
• W1986703630 title "Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study" @default.
• W1986703630 cites W1966721630 @default.
• W1986703630 cites W1987604596 @default.
• W1986703630 cites W2007783923 @default.
• W1986703630 cites W2058709767 @default.
• W1986703630 cites W2096079570 @default.
• W1986703630 cites W2118291016 @default.
• W1986703630 doi "https://doi.org/10.1016/j.atherosclerosis.2005.12.012" @default.
• W1986703630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16445917" @default.
• W1986703630 hasPublicationYear "2006" @default.
• W1986703630 type Work @default.
• W1986703630 sameAs 1986703630 @default.
• W1986703630 citedByCount "48" @default.
• W1986703630 countsByYear W19867036302012 @default.
• W1986703630 countsByYear W19867036302013 @default.
• W1986703630 countsByYear W19867036302014 @default.
• W1986703630 countsByYear W19867036302015 @default.
• W1986703630 countsByYear W19867036302016 @default.
• W1986703630 countsByYear W19867036302018 @default.
• W1986703630 countsByYear W19867036302019 @default.
• W1986703630 countsByYear W19867036302020 @default.
• W1986703630 countsByYear W19867036302021 @default.
• W1986703630 countsByYear W19867036302022 @default.
• W1986703630 countsByYear W19867036302023 @default.
• W1986703630 crossrefType "journal-article" @default.
• W1986703630 hasAuthorship W1986703630A5000325789 @default.
• W1986703630 hasAuthorship W1986703630A5009252391 @default.
• W1986703630 hasAuthorship W1986703630A5018378907 @default.
• W1986703630 hasAuthorship W1986703630A5018722034 @default.
• W1986703630 hasAuthorship W1986703630A5020734267 @default.
• W1986703630 hasAuthorship W1986703630A5057919043 @default.
• W1986703630 hasAuthorship W1986703630A5072295805 @default.
• W1986703630 hasConcept C104317684 @default.
• W1986703630 hasConcept C126322002 @default.
• W1986703630 hasConcept C134018914 @default.
• W1986703630 hasConcept C135763542 @default.
• W1986703630 hasConcept C180754005 @default.
• W1986703630 hasConcept C2776839432 @default.
• W1986703630 hasConcept C2776914184 @default.
• W1986703630 hasConcept C2778143017 @default.
• W1986703630 hasConcept C2778163477 @default.
• W1986703630 hasConcept C2779134260 @default.
• W1986703630 hasConcept C2781195455 @default.
• W1986703630 hasConcept C54355233 @default.
• W1986703630 hasConcept C57089818 @default.
• W1986703630 hasConcept C62746215 @default.
• W1986703630 hasConcept C71924100 @default.
• W1986703630 hasConcept C72563966 @default.
• W1986703630 hasConcept C86803240 @default.
• W1986703630 hasConcept C90924648 @default.
• W1986703630 hasConceptScore W1986703630C104317684 @default.
• W1986703630 hasConceptScore W1986703630C126322002 @default.
• W1986703630 hasConceptScore W1986703630C134018914 @default.
• W1986703630 hasConceptScore W1986703630C135763542 @default.
• W1986703630 hasConceptScore W1986703630C180754005 @default.
• W1986703630 hasConceptScore W1986703630C2776839432 @default.
• W1986703630 hasConceptScore W1986703630C2776914184 @default.
• W1986703630 hasConceptScore W1986703630C2778143017 @default.
• W1986703630 hasConceptScore W1986703630C2778163477 @default.
• W1986703630 hasConceptScore W1986703630C2779134260 @default.
• W1986703630 hasConceptScore W1986703630C2781195455 @default.
• W1986703630 hasConceptScore W1986703630C54355233 @default.
• W1986703630 hasConceptScore W1986703630C57089818 @default.
• W1986703630 hasConceptScore W1986703630C62746215 @default.
• W1986703630 hasConceptScore W1986703630C71924100 @default.
• W1986703630 hasConceptScore W1986703630C72563966 @default.
• W1986703630 hasConceptScore W1986703630C86803240 @default.
• W1986703630 hasConceptScore W1986703630C90924648 @default.
• W1986703630 hasIssue "1" @default.
• W1986703630 hasLocation W19867036301 @default.
• W1986703630 hasLocation W19867036302 @default.
• W1986703630 hasOpenAccess W1986703630 @default.
• W1986703630 hasPrimaryLocation W19867036301 @default.
• W1986703630 hasRelatedWork W1836056895 @default.
• W1986703630 hasRelatedWork W2036221901 @default.
• W1986703630 hasRelatedWork W2063661367 @default.
• W1986703630 hasRelatedWork W2073251079 @default.
• W1986703630 hasRelatedWork W2080322132 @default.
• W1986703630 hasRelatedWork W2389304242 @default.
• W1986703630 hasRelatedWork W2437007603 @default.
• W1986703630 hasRelatedWork W3032294988 @default.
• W1986703630 hasRelatedWork W3133932439 @default.
• W1986703630 hasRelatedWork W4385271902 @default.
• W1986703630 hasVolume "186" @default.
• W1986703630 isParatext "false" @default.
• W1986703630 isRetracted "false" @default.
• W1986703630 magId "1986703630" @default.

• next