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• W1986709000 abstract "Abstract : The ability of thymosin α1 (Tα1) to prevent lung and breast cancer was investigated. Lung adenomas developed in A/J mice injected with carcinogens, such as urethane. The lung adenoma number was reduced by 15–45% if animals were daily treated subcutaneously (s.c.) with Tα1 (0.4 mg/kg). Tα1 (1 μM) directly inhibited the growth of mouse lung cell lines. These results suggest that Tα1 may prevent mouse lung carcinogenesis because it directly inhibits the growth of lung cancer cells. Tα1 prevented mammary carcinogenesis in two animal models. In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N‐methylurea (NMU). The rat survival was significantly increased by the daily injection of Tα1. In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor‐independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Tα1. These results indicate that Tα1 is a chemopreventive agent in animal models for lung and breast carcinogenesis." @default.
• W1986709000 created "2016-06-24" @default.
• W1986709000 creator A5045282985 @default.
• W1986709000 date "2007-09-01" @default.
• W1986709000 modified "2023-10-09" @default.
• W1986709000 title "Thymosin α1 as a Chemopreventive Agent in Lung and Breast Cancer" @default.
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• W1986709000 doi "https://doi.org/10.1196/annals.1415.040" @default.
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