FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986718719> ?p ?o ?g. }

• W1986718719 endingPage "102" @default.
• W1986718719 startingPage "91" @default.
• W1986718719 abstract "Calcineurin (CN), the only Ca(2+)/calmodulin-activated serine/threonine protein phosphatase, is a key effector participating in Ca(2+)-dependent signal transduction pathways in a number of cellular processes under normal, stress and pathological conditions. However, the expression and the relevance of CN in stress and immune response have not been characterized in crustaceans. Here, we identified the cDNAs that encode the two subunits of CN (termed EsCN-A and EsCN-B, respectively) in Chinese mitten crab Eriocheir sinensis and analysed their expression patterns in response to stress and immune challenges. The catalytic subunit EsCN-A is comprised of 511 amino acids with a theoretical molecular mass of 57.5 kDa and shows 80% sequence identity with human beings CN-A alpha isoform, while the regulatory subunit EsCN-B protein is composed of 170 amino acids with an estimated molecular mass of 19.3 kDa and shares 88% sequence identity with human beings CN-B type 1. Tissue distribution analysis reveals that both EsCN-A and EsCN-B mRNA transcripts are expressed in all tested tissues with the greatest expression in hepatopancreas and the lowest expression in haemocytes. In addition, both EsCN-A and EsCN-B genes could be significantly up-regulated but with different expression patterns by ambient salinity (15‰ and 30‰ salinities) and pH (pH 6 and 8.5) stresses in gill, hepatopancreas, haemocytes, intestine and muscle. Furthermore, EsCN-A and EsCN-B were up-regulated by LPS and Poly(I:C) immune stimulations in E. sinensis haemocytes in vitro. Moreover, EsCN-A and EsCN-B mRNA were significantly up-regulated in haemocytes, gill, hepatopancreas, intestine and muscle in response to Edwardsiella tarda challenge in vivo. Finally, we revealed the importance of EsCN in LPS-induced nitric oxide production in E. sinensis haemocytes. Together our observations suggest that EsCN, the important downstream effector of CaM-mediated signalling pathway(s), may possess vital roles in stress and immune response in the Chinese mitten crab." @default.
• W1986718719 created "2016-06-24" @default.
• W1986718719 creator A5007612048 @default.
• W1986718719 creator A5033286474 @default.
• W1986718719 creator A5042785839 @default.
• W1986718719 creator A5043296622 @default.
• W1986718719 creator A5066441182 @default.
• W1986718719 date "2015-03-01" @default.
• W1986718719 modified "2023-10-14" @default.
• W1986718719 title "Identification and characterization of the cDNAs encoding the two subunits of Chinese mitten crab (Eriocheir sinensis) calcineurin: Their implications in stress and immune response" @default.
• W1986718719 cites W1563034495 @default.
• W1986718719 cites W1913741367 @default.
• W1986718719 cites W19446119 @default.
• W1986718719 cites W1967336595 @default.
• W1986718719 cites W1970842110 @default.
• W1986718719 cites W1983321429 @default.
• W1986718719 cites W1984754431 @default.
• W1986718719 cites W1989374991 @default.
• W1986718719 cites W1990026683 @default.
• W1986718719 cites W1991163286 @default.
• W1986718719 cites W1991332015 @default.
• W1986718719 cites W1992117613 @default.
• W1986718719 cites W1994673402 @default.
• W1986718719 cites W1998514259 @default.
• W1986718719 cites W2003801062 @default.
• W1986718719 cites W2008934230 @default.
• W1986718719 cites W2010814483 @default.
• W1986718719 cites W2012165823 @default.
• W1986718719 cites W2020955202 @default.
• W1986718719 cites W2021578845 @default.
• W1986718719 cites W2031053624 @default.
• W1986718719 cites W2041360509 @default.
• W1986718719 cites W2041907692 @default.
• W1986718719 cites W2047668093 @default.
• W1986718719 cites W2053139786 @default.
• W1986718719 cites W2059912147 @default.
• W1986718719 cites W2063858805 @default.
• W1986718719 cites W2066222426 @default.
• W1986718719 cites W2081358368 @default.
• W1986718719 cites W2083477308 @default.
• W1986718719 cites W2086141071 @default.
• W1986718719 cites W2086208660 @default.
• W1986718719 cites W2086651422 @default.
• W1986718719 cites W2107277218 @default.
• W1986718719 cites W2116025920 @default.
• W1986718719 cites W2118662818 @default.
• W1986718719 cites W2121972996 @default.
• W1986718719 cites W2124871086 @default.
• W1986718719 cites W2128603984 @default.
• W1986718719 cites W2130900795 @default.
• W1986718719 cites W2159599963 @default.
• W1986718719 cites W2162398836 @default.
• W1986718719 cites W2170693414 @default.
• W1986718719 cites W2172196619 @default.
• W1986718719 cites W2178456244 @default.
• W1986718719 doi "https://doi.org/10.1016/j.fsi.2014.12.020" @default.
• W1986718719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25541080" @default.
• W1986718719 hasPublicationYear "2015" @default.
• W1986718719 type Work @default.
• W1986718719 sameAs 1986718719 @default.
• W1986718719 citedByCount "6" @default.
• W1986718719 countsByYear W19867187192016 @default.
• W1986718719 countsByYear W19867187192017 @default.
• W1986718719 countsByYear W19867187192020 @default.
• W1986718719 countsByYear W19867187192021 @default.
• W1986718719 crossrefType "journal-article" @default.
• W1986718719 hasAuthorship W1986718719A5007612048 @default.
• W1986718719 hasAuthorship W1986718719A5033286474 @default.
• W1986718719 hasAuthorship W1986718719A5042785839 @default.
• W1986718719 hasAuthorship W1986718719A5043296622 @default.
• W1986718719 hasAuthorship W1986718719A5066441182 @default.
• W1986718719 hasConcept C104292427 @default.
• W1986718719 hasConcept C104317684 @default.
• W1986718719 hasConcept C128057223 @default.
• W1986718719 hasConcept C140793950 @default.
• W1986718719 hasConcept C141071460 @default.
• W1986718719 hasConcept C153911025 @default.
• W1986718719 hasConcept C167625842 @default.
• W1986718719 hasConcept C181199279 @default.
• W1986718719 hasConcept C2776408259 @default.
• W1986718719 hasConcept C2776414213 @default.
• W1986718719 hasConcept C2778914303 @default.
• W1986718719 hasConcept C2780710107 @default.
• W1986718719 hasConcept C2911091166 @default.
• W1986718719 hasConcept C55493867 @default.
• W1986718719 hasConcept C71924100 @default.
• W1986718719 hasConcept C86803240 @default.
• W1986718719 hasConceptScore W1986718719C104292427 @default.
• W1986718719 hasConceptScore W1986718719C104317684 @default.
• W1986718719 hasConceptScore W1986718719C128057223 @default.
• W1986718719 hasConceptScore W1986718719C140793950 @default.
• W1986718719 hasConceptScore W1986718719C141071460 @default.
• W1986718719 hasConceptScore W1986718719C153911025 @default.
• W1986718719 hasConceptScore W1986718719C167625842 @default.
• W1986718719 hasConceptScore W1986718719C181199279 @default.
• W1986718719 hasConceptScore W1986718719C2776408259 @default.
• W1986718719 hasConceptScore W1986718719C2776414213 @default.
• W1986718719 hasConceptScore W1986718719C2778914303 @default.

• next