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- W1986733854 abstract "A full-length cDNA of a novel cadherin of chicken (cad10) was cloned. The deduced amino acid sequence of the putative cytoplasmic domain of this molecule is highly homologous to a previously published cytoplasmic fragment of human cadherin-10, a type II cadherin. An in situ hybridization analysis in chicken embryos shows that cad10 expression starts at about 4 days' incubation (E4) and persists at least until the hatching stage. In the central nervous system (CNS), cad10 expression is spatially restricted at all stages of development. At early stages, expression reflects the neuromeric organization of the brain. For example, in the alar plate of the diencephalon, cad10 expression is restricted to the dorsal thalamic neuromere. A number of cad10-expressing brain nuclei are formed in this neuromeric domain during later development. Specific cad10-expressing gray matter structures are also found in all other major divisions of the brain. Many of these structures are known to be functionally connected to each other. The cad10 expression pattern is distinct from that of other cadherins. These results support the idea that cadherins provide a molecular code for the regionalization of the embryonic CNS at the different stages of development. Dev. Dyn. 209:269–285, 1997. © 1997 Wiley-Liss, Inc." @default.
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- W1986733854 date "1997-07-01" @default.
- W1986733854 modified "2023-10-12" @default.
- W1986733854 title "Cloning and expression analysis of cadherin-10 in the CNS of the chicken embryo" @default.
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- W1986733854 doi "https://doi.org/10.1002/(sici)1097-0177(199707)209:3<269::aid-aja3>3.0.co;2-g" @default.
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