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• W1986743366 startingPage "372" @default.
• W1986743366 abstract "Glutathione transferases (GSTs) are essential enzymes in many organisms due their diverse functions and, in helminths they are the main detoxification system. For Taenia solium, two cytosolic GSTs with molecular masses of 25.5 and 26.5 kDa (Ts26GST) have been found. Ts26GST was cloned to be studied in its recombinant form (recTs26GST). Although the primary structure is related to the mu class, the kinetic parameters for CDNB (V(max)=51.5 micromol min(-1)mg(-1); K(m)=1.06 mM; k(cat)= 22.2s(-1)) are related with some alpha GSTs. The substrate and inhibitor class markers reaffirmed these bimodal characteristics. Inhibition studies with anthelminthics indicate that recTs26GST is sensitive to mebendazole, displaying a non competitive inhibition pattern suggesting that at least two molecules are binding to recTs26GST. On the other hand, the kinetic curves for CDNB and GSH showed a positive cooperativity that was corroborated using fluorometric assays. Those assays indicate that CDNB binding is highly influenced by GSH, probably by modulation of the Ts26GST conformational ensamble." @default.
• W1986743366 created "2016-06-24" @default.
• W1986743366 creator A5014952001 @default.
• W1986743366 creator A5024590293 @default.
• W1986743366 date "2008-09-01" @default.
• W1986743366 modified "2023-10-03" @default.
• W1986743366 title "Cooperative kinetics of the recombinant glutathione transferase of Taenia solium and characterization of the enzyme" @default.
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• W1986743366 doi "https://doi.org/10.1016/j.abb.2008.07.008" @default.
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